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Reisinger, AC; Posch, F; Hackl, G; Marsche, G; Sourij, H; Bourgeois, B; Eller, K; Madl, T; Eller, P.
Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients.
Nutrients. 2021; 13(9): Doi: 10.3390/nu13093106 [OPEN ACCESS]
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Leading authors Med Uni Graz: Eller Philipp; Madl Tobias; Reisinger Alexander Christian
Co-authors Med Uni Graz: Bourgeois Benjamin Michel Rene; Eller Kathrin; Hackl Gerald; Marsche Gunther; Posch Florian; Sourij Harald
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Abstract:: Sepsis biomarkers and potential therapeutic targets are urgently needed. With proton nuclear magnetic resonance (¹H NMR) spectroscopy, several metabolites can be assessed simultaneously. Fifty-three adult medical ICU sepsis patients and 25 ICU controls without sepsis were prospectively enrolled. ¹H NMR differences between groups and associations with 28-day and ICU mortality were investigated. In multivariate metabolomic analyses, we found separate clustering of ICU controls and sepsis patients, as well as septic shock survivors and non-survivors. Lipoproteins were significantly different between sepsis and control patients. Levels of the branched-chain amino acids (BCAA) valine (median 43.3 [29.0-53.7] vs. 64.3 [47.7-72.3] normalized signal intensity units; p = 0.005), leucine (57.0 [38.4-71.0] vs. 73.0 [54.3-86.3]; p = 0.034) and isoleucine (15.2 [10.9-21.6] vs. 17.9 [16.1-24.4]; p = 0.048) were lower in patients with septic shock compared to those without. Similarly, BCAA were lower in ICU non-survivors compared to survivors, and BCAA were good discriminators for ICU and 28-day mortality. In uni- and multivariable logistic regression analyses, higher BCAA levels were associated with decreased ICU- and 28-day mortality. In conclusion, metabolomics using ¹H NMR spectroscopy showed encouraging potential for personalized medicine in sepsis. BCAA was significantly lower in sepsis non-survivors and may be used as early biomarkers for outcome prediction.
Find related publications in this database (Keywords): sepsis; ICU; metabolomics; NMR spectroscopy; branched-chain amino acids; lipoproteins