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Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Obermayer, A; Tripolt, NJ; Aziz, F; Högenauer, C; Aberer, F; Schreiber, F; Eherer, A; Sourij, C; Stadlbauer, V; Svehlikova, E; Brunner, M; Goswami, N; Kojzar, H; Pferschy, PN; Pieber, TR; Sourij, H.
EndoBarrier™ Implantation Rapidly Improves Insulin Sensitivity in Obese Individuals with Type 2 Diabetes Mellitus.
Biomolecules. 2021; 11(4): Doi: 10.3390/biom11040574 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Leading authors Med Uni Graz
Obermayer Anna Maria Antonia
Sourij Harald
Co-authors Med Uni Graz
Aberer Felix
Aziz Faisal
Brunner Martina
Eherer Andreas
Goswami Nandu
Hoegenauer Christoph
Kojzar Harald
Pferschy Peter
Pieber Thomas
Schreiber Florian
Sourij Caren
Stadlbauer-Köllner Vanessa
Svehlikova Eva
Tripolt Norbert

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

The EndoBarrier™ medical device is a duodenal-jejunal bypass liner designed to mimic the effects of gastric bypass surgery to induce weight loss and glycaemic improvement. In this study, 10 participants with type 2 diabetes mellitus (T2DM), a mean body mass index (BMI) of 43.3 ± 5.0 (kg/m2) and a mean glycated haemoglobin A1c (HbA1c) of 60.6 ± 8.6 mmol/mol were examined at baseline (before implantation of EndoBarrier™), 4 weeks after implantation, at 36 weeks (right before explantation) and 24 weeks after the removal of the device to explore the short and long-term effects on glucose metabolism. Besides a significant reduction in body weight and fat mass, EndoBarrier™ treatment significantly improved insulin sensitivity during Botnia clamp investigations after four weeks of implantation. The beneficial effects decreased over time but remained significant 24 weeks after removal of the device.
Find related publications in this database (using NLM MeSH Indexing)
Adiposity - administration & dosage
Adult - administration & dosage
Bariatric Surgery - instrumentation, methods
Blood Glucose - metabolism
Diabetes Mellitus, Type 2 - complications, surgery
Female - administration & dosage
Glycated Hemoglobin - metabolism
Humans - administration & dosage
Insulin Resistance - administration & dosage
Jejunum - surgery
Male - administration & dosage
Middle Aged - administration & dosage
Obesity - complications, surgery
Prostheses and Implants - administration & dosage
Weight Loss - administration & dosage

Find related publications in this database (Keywords)
EndoBarrier (TM)
duodenal-jejunal bypass liner
type 2 diabetes mellitus
Botnia clamp
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