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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Obermayer, A; Tripolt, NJ; Aziz, F; Högenauer, C; Aberer, F; Schreiber, F; Eherer, A; Sourij, C; Stadlbauer, V; Svehlikova, E; Brunner, M; Goswami, N; Kojzar, H; Pferschy, PN; Pieber, TR; Sourij, H.
EndoBarrier™ Implantation Rapidly Improves Insulin Sensitivity in Obese Individuals with Type 2 Diabetes Mellitus.
Biomolecules. 2021; 11(4):
Doi: 10.3390/biom11040574
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- Leading authors Med Uni Graz
- Obermayer Anna Maria Antonia
- Sourij Harald
- Co-authors Med Uni Graz
- Aberer Felix
- Aziz Faisal
- Brunner Martina
- Eherer Andreas
- Goswami Nandu
- Hoegenauer Christoph
- Kojzar Harald
- Pferschy Peter
- Pieber Thomas
- Schreiber Florian
- Sourij Caren
- Stadlbauer-Köllner Vanessa
- Svehlikova Eva
- Tripolt Norbert
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- Abstract:
- The EndoBarrier™ medical device is a duodenal-jejunal bypass liner designed to mimic the effects of gastric bypass surgery to induce weight loss and glycaemic improvement. In this study, 10 participants with type 2 diabetes mellitus (T2DM), a mean body mass index (BMI) of 43.3 ± 5.0 (kg/m2) and a mean glycated haemoglobin A1c (HbA1c) of 60.6 ± 8.6 mmol/mol were examined at baseline (before implantation of EndoBarrier™), 4 weeks after implantation, at 36 weeks (right before explantation) and 24 weeks after the removal of the device to explore the short and long-term effects on glucose metabolism. Besides a significant reduction in body weight and fat mass, EndoBarrier™ treatment significantly improved insulin sensitivity during Botnia clamp investigations after four weeks of implantation. The beneficial effects decreased over time but remained significant 24 weeks after removal of the device.
- Find related publications in this database (using NLM MeSH Indexing)
- Adiposity - administration & dosage
- Adult - administration & dosage
- Bariatric Surgery - instrumentation, methods
- Blood Glucose - metabolism
- Diabetes Mellitus, Type 2 - complications, surgery
- Female - administration & dosage
- Glycated Hemoglobin - metabolism
- Humans - administration & dosage
- Insulin Resistance - administration & dosage
- Jejunum - surgery
- Male - administration & dosage
- Middle Aged - administration & dosage
- Obesity - complications, surgery
- Prostheses and Implants - administration & dosage
- Weight Loss - administration & dosage
- Find related publications in this database (Keywords)
- EndoBarrier (TM)
- obesity
- duodenal-jejunal bypass liner
- type 2 diabetes mellitus
- Botnia clamp