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SHR Neuro Cancer Cardio Lipid Metab Microb

Mir, Seyed, Nazari, P; Berghoff, AS; Preusser, M; Moik, F; Posch, F; Ricken, G; Riedl, J; Hell, L; Marosi, C; Hainfellner, JA; Pabinger, I; Ay, C.
Association of programmed cell death ligand 1 and circulating lymphocytes with risk of venous thromboembolism in patients with glioma.
ESMO Open. 2020; 5(3):e000647 Doi: 10.1136/esmoopen-2019-000647 [OPEN ACCESS]
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Co-authors Med Uni Graz
Moik Florian
Posch Florian

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INTRODUCTION: The role of the adaptive immune system in the pathophysiology of cancer-associated venous thromboembolism (VTE) has not been investigated in detail. Programmed cell death ligand 1 (PD-L1) is an immune checkpoint molecule responsible for immune evasion in several cancer entities, as expression on tumour cells silences the T cell-mediated immune response. Given the interrelation between inflammation, haemostasis and cancer, we aimed to investigate the association of players of the adaptive immunity (eg, lymphocytes, tumour PD-L1) with risk of VTE in patients with glioma, one of the most prothrombotic cancer types. METHODS: In this prospective observational single-centre cohort study, patients with newly diagnosed glioma or regrowth after resection were included. Primary endpoint was objectively confirmed VTE. At study inclusion, a blood draw was performed. Tumour PD-L1 expression was assessed via immunohistochemistry. RESULTS: In total, 193 patients were included. PD-L1 expression in ≥1% of tumour cells was observed in 20/193 (10.4%) glioma. In multivariable cox-regression analysis, on adjustment for age, sex and WHO grade IV, systemic lymphocyte counts were significantly associated with risk of VTE (HR per 1 G/L increase (95% CI): 1.15 (1.03 to 1.29), p=0.013). In contrast, no significant difference in risk of VTE was found regarding the PD-L1 status: the cumulative 24 months probability of VTE was 17.0% in patients with no PD-L1 and 11.8% in those with PD-L1 expressing tumours (p=0.663). CONCLUSION: In summary, PD-L1 expression was not associated with risk of VTE. Interestingly, peripheral lymphocytes, which are key players in adaptive immunity, were linked to an increased risk of glioma-associated VTE.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Aged - administration & dosage
Apoptosis - administration & dosage
B7-H1 Antigen - metabolism
Cohort Studies - administration & dosage
Female - administration & dosage
Glioma - administration & dosage
Humans - administration & dosage
Ligands - administration & dosage
Lymphocytes - administration & dosage
Male - administration & dosage
Middle Aged - administration & dosage
Venous Thromboembolism - administration & dosage

Find related publications in this database (Keywords)
venous thromboembolism
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