Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Fissolo, N; Cervera-Carles, L; Villar Guimerans, LM; Lleó, A; Clarimón, J; Drulovic, J; Dujmovic, I; Voortman, M; Khalil, M; Gil, E; Navarro, L; Álvarez-Cermeño, JC; Montalban, X; Comabella, M.
Cerebrospinal fluid mitochondrial DNA levels in patients with multiple sclerosis.
Mult Scler. 2019; 25(11):1535-1538
Doi: 10.1177/1352458518786055
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Khalil Michael
- Voortman Margarete Maria
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- Abstract:
- The role of cerebrospinal fluid (CSF) mitochondrial DNA (mtDNA) levels as biomarker in multiple sclerosis (MS) is unknown. We determined CSF mtDNA levels in a cohort of 237 individuals, including patients with MS and clinically isolated syndrome (CIS), inflammatory and non-inflammatory neurological controls, and cognitively healthy controls (HC). mtDNA concentration was measured by droplet digital polymerase chain reaction. CSF mtDNA levels were increased in all pathological conditions compared with HC, though no differences were observed between relapse-onset and progressive MS clinical forms, CIS patients and neurological controls. These findings do not support the determination of CSF mtDNA levels as a useful biomarker in MS clinical practice.
- Find related publications in this database (Keywords)
- Mitochondrial DNA
- cerebrospinal fluid
- multiple sclerosis
- droplet digital PCR