Medizinische Universität Graz - Research portal

Logo MUG Resarch Portal

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Grübler, MR; März, W; Pilz, S; Grammer, TB; Trummer, C; Müllner, C; Schwetz, V; Pandis, M; Verheyen, N; Tomaschitz, A; Fiordelisi, A; Laudisio, D; Cipolletta, E; Iaccarino, G.
Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence.
Rev Endocr Metab Disord. 2017; 18(2):259-272 Doi: 10.1007/s11154-017-9417-0 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG


Leading authors Med Uni Graz
Grübler Martin
Co-authors Med Uni Graz
März Winfried
Pandis Marlene
Pilz Stefan
Theiler-Schwetz Verena
Tomaschitz Andreas
Trummer Christian
Verheyen Nicolas Dominik

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Vitamin D has long been established as an elemental factor of bone physiology. Beyond mineral metabolism, the expression of the vitamin D receptor has been identified throughout the cardiovascular (CV) system. Experimental studies showed beneficial effects of vitamin D on heart and vessels, but vitamin D intoxication in animals also led to hypercalcemia and vascular calcification. Our knowledge has been extended by epidemiological studies that showed that 25-hydroxyvitamin D (25(OH)D) levels are inversely associated with an increased CV risk itself, but also with established CV risk factors, such as arterial hypertension, endothelial dysfunction and atherosclerosis. Conversely, randomized controlled trials could not document significant and consistent effects of vitamin D supplementation on CV risk or events. Potential explanations may lie in differences in reference ranges or the possibility that low vitamin D in CV disease is only an epiphenomenon. In the latter case, the key question is why low 25(OH)D levels are such a strong predictor of health. While we wait for new data, the current conclusion is that vitamin D is a strong risk marker for CV risk factors and for CV diseases itself.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Cardiovascular System - drug effects
Cardiovascular System - metabolism
Humans -
Risk Factors -
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D - pharmacology
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology

Find related publications in this database (Keywords)
Vitamin D
Vitamin D receptor
Cardiovascular risk
© Med Uni GrazImprint