Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Grübler, MR; März, W; Pilz, S; Grammer, TB; Trummer, C; Müllner, C; Schwetz, V; Pandis, M; Verheyen, N; Tomaschitz, A; Fiordelisi, A; Laudisio, D; Cipolletta, E; Iaccarino, G.
Vitamin-D concentrations, cardiovascular risk and events - a review of epidemiological evidence.
Rev Endocr Metab Disord. 2017; 18(2):259-272
Doi: 10.1007/s11154-017-9417-0
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- Leading authors Med Uni Graz
- Grübler Martin
- Co-authors Med Uni Graz
- März Winfried
- Pandis Marlene
- Pilz Stefan
- Theiler-Schwetz Verena
- Tomaschitz Andreas
- Trummer Christian
- Verheyen Nicolas Dominik
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- Abstract:
- Vitamin D has long been established as an elemental factor of bone physiology. Beyond mineral metabolism, the expression of the vitamin D receptor has been identified throughout the cardiovascular (CV) system. Experimental studies showed beneficial effects of vitamin D on heart and vessels, but vitamin D intoxication in animals also led to hypercalcemia and vascular calcification. Our knowledge has been extended by epidemiological studies that showed that 25-hydroxyvitamin D (25(OH)D) levels are inversely associated with an increased CV risk itself, but also with established CV risk factors, such as arterial hypertension, endothelial dysfunction and atherosclerosis. Conversely, randomized controlled trials could not document significant and consistent effects of vitamin D supplementation on CV risk or events. Potential explanations may lie in differences in reference ranges or the possibility that low vitamin D in CV disease is only an epiphenomenon. In the latter case, the key question is why low 25(OH)D levels are such a strong predictor of health. While we wait for new data, the current conclusion is that vitamin D is a strong risk marker for CV risk factors and for CV diseases itself.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cardiovascular Diseases - blood
- Cardiovascular Diseases - epidemiology
- Cardiovascular Diseases - etiology
- Cardiovascular System - drug effects
- Cardiovascular System - metabolism
- Humans -
- Risk Factors -
- Vitamin D - analogs & derivatives
- Vitamin D - blood
- Vitamin D - pharmacology
- Vitamin D Deficiency - blood
- Vitamin D Deficiency - complications
- Vitamin D Deficiency - epidemiology
- Find related publications in this database (Keywords)
- Vitamin D
- Cardiovascular
- Mortality
- Vitamin D receptor
- Epidemiology
- Cardiovascular risk
- Review