Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Deutsch, AJA; Rinner, B; Pichler, M; Prochazka, K; Pansy, K; Bischof, M; Fechter, K; Hatzl, S; Feichtinger, J; Wenzl, K; Frisch, MT; Stiegelbauer, V; Prokesch, A; Krogsdam, A; Sill, H; Thallinger, GG; Greinix, HT; Wang, C; Beham-Schmid, C; Neumeister, P.
NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes.
Cancer Res. 2017; 77(9):2375-2386
Doi: 10.1158/0008-5472.CAN-16-2320
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- Leading authors Med Uni Graz
- Deutsch Alexander
- Co-authors Med Uni Graz
- Beham-Schmid Christine
- Fechter Karoline
- Feichtinger Julia
- Greinix Hildegard
- Hatzl Stefan
- Melcher Marie-Therese
- Neumeister Peter
- Pansy Katrin
- Pichler Martin
- Prochazka Katharina
- Prokesch Andreas
- Rinner Beate
- Sill Heinz
- Stiegelbauer Verena
- Wenzl Kerstin
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- Abstract:
- Nuclear orphan receptor NR4A1 exerts an essential tumor suppressor function in aggressive lymphomas. In this study, we investigated the hypothesized contribution of the related NR4A family member NR4A3 to lymphomagenesis. In aggressive lymphoma patients, low expression of NR4A3 was associated with poor survival. Ectopic expression or pharmacological activation of NR4A3 in lymphoma cell lines led to a significantly higher proportion of apoptotic cells. In a mouse NSG xenograft model of lymphoma (stably transduced SuDHL4 cells), NR4A3 expression abrogated tumor growth, compared with vector control and uninduced cells that formed massive tumors. Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 or NR4A1 revealed that apoptosis was driven similarly by induction of BAK, Puma, BIK, BIM, BID, and Trail. Overall, our results showed that NR4A3 possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas. Cancer Res; 77(9); 2375-86. ©2017 AACR. ©2017 American Association for Cancer Research.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Apoptosis - genetics
- Carcinogenesis - genetics
- Cell Line, Tumor -
- Cell Proliferation - genetics
- DNA-Binding Proteins - biosynthesis
- DNA-Binding Proteins - genetics
- Disease-Free Survival -
- Female -
- Gene Expression Regulation, Neoplastic -
- Humans -
- Kaplan-Meier Estimate -
- Lymphoma - genetics
- Lymphoma - pathology
- Male -
- Mice -
- Receptors, Steroid - biosynthesis
- Receptors, Steroid - genetics
- Receptors, Thyroid Hormone - biosynthesis
- Receptors, Thyroid Hormone - genetics
- Xenograft Model Antitumor Assays -