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Fruhwald, S; Pollesello, P; Fruhwald, F.
Advanced heart failure: an appraisal of the potential of levosimendan in this end-stage scenario and some related ethical considerations.
Expert Rev Cardiovasc Ther. 2016; 14(12):1335-1347 Doi: 10.1080/14779072.2016.1247694 [OPEN ACCESS]
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Leading authors Med Uni Graz
Fruhwald Sonja
Co-authors Med Uni Graz
Fruhwald Friedrich
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Abstract:
The later stages of heart failure are characterized by a steady decline in quality of life. Clinical priorities should be to maintain functional capacity and quality of life. In the absence of sufficient organs for transplantation, options include left ventricular assist devices and inotropic support. Areas covered: We examined data published in the last two decades on the use of inotropes and inodilators in advanced heart failure. Expert commentary: In the literature, use of conventional inotropes, including adrenergic agonists and phosphodiesterase inhibitors, appears to be suboptimal for achieving the clinical priorities of late-stage heart failure. Evidence suggests instead that the calcium-sensitizing inodilator levosimendan, administered intermittently, delivers improvements in functional capacity and quality of life and does so with no adverse impact on life expectancy. At a terminal or near-terminal stage of heart failure, the therapeutic philosophy should shift towards meeting patients' existential priorities rather than traditional heart failure-centric targets.
Find related publications in this database (using NLM MeSH Indexing)
Cardiotonic Agents - therapeutic use
Heart Failure - physiopathology
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Hydrazones - therapeutic use
Pyridazines - therapeutic use
Quality of Life -
Simendan -

Find related publications in this database (Keywords)
Heart failure
palliative care
inodilator
levosimendan
quality of life
ethics
kidney function
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