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SHR Neuro Cancer Cardio Lipid Metab Microb

Pirpamer, L; Hofer, E; Gesierich, B; De Guio, F; Freudenberger, P; Seiler, S; Duering, M; Jouvent, E; Duchesnay, E; Dichgans, M; Ropele, S; Schmidt, R.
Determinants of iron accumulation in the normal aging brain.
Neurobiol Aging. 2016; 43(32):149-155 Doi: 10.1016/j.neurobiolaging.2016.04.002
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Leading authors Med Uni Graz
Pirpamer Lukas
Schmidt Reinhold
Co-authors Med Uni Graz
Freudenberger Paul
Hofer Edith
Ropele Stefan
Seiler Stephan

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In a recent postmortem study, R2* relaxometry in gray matter (GM) of the brain has been validated as a noninvasive measure for iron content in brain tissue. Iron accumulation in the normal aging brain is a common finding and relates to brain maturation and degeneration. The goal of this study was to assess the determinants of iron accumulation during brain aging. The study cohort consisted of 314 healthy community-dwelling participants of the Austrian Stroke Prevention Study. Their age ranged from 38-82 years. Quantitative magnetic resonance imaging was performed on 3T and included R2* mapping, based on a 3D multi-echo gradient echo sequence. The median of R2* values was measured in all GM regions, which were segmented automatically using FreeSurfer. We investigated 25 possible determinants for cerebral iron deposition. These included demographics, brain volume, lifestyle factors, cerebrovascular risk factors, serum levels of iron, and single nucleotide polymorphisms related to iron regulating genes (rs1800562, rs3811647, rs1799945, and rs1049296). The body mass index (BMI) was significantly related to R2* in 15/32 analyzed brain regions with the strongest correlations found in the amygdala (p = 0.0091), medial temporal lobe (p = 0.0002), and hippocampus (p ≤ 0.0001). Further associations to R2* values were found in deep GM for age and smoking. No significant associations were found for gender, GM volume, serum levels of iron, or iron-associated genetic polymorphisms. In conclusion, besides age, the BMI and smoking are the only significant determinants of brain iron accumulation in normally aging subjects. Smoking relates to iron deposition in the basal ganglia, whereas higher BMI is associated with iron content in the neocortex following an Alzheimer-like distribution. Copyright © 2016 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Aging - metabolism
Body Mass Index -
Brain - diagnostic imaging
Brain - metabolism
Brain - pathology
Cohort Studies -
Female -
Humans -
Iron - metabolism
Magnetic Resonance Imaging -
Male -
Middle Aged -
Smoking - adverse effects

Find related publications in this database (Keywords)
Determinants for iron accumulation
Normal aging brain
R-2* brain iron mapping
Magnetic resonance imaging
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