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SHR Neuro Cancer Cardio Lipid Metab Microb

Grübler, MR; Kienreich, K; Gaksch, M; Verheyen, N; Hartaigh, BÓ; Fahrleitner-Pammer, A; März, W; Schmid, J; Oberreither, EM; Wetzel, J; Catena, C; Sechi, LA; Pieske, B; Tomaschitz, A; Pilz, S.
Aldosterone-to-Renin Ratio Is Associated With Reduced 24-Hour Heart Rate Variability and QTc Prolongation in Hypertensive Patients.
Medicine (Baltimore). 2016; 95(8):e2794 Doi: 10.1097/MD.0000000000002794 [OPEN ACCESS]
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Leading authors Med Uni Graz
Grübler Martin
Co-authors Med Uni Graz
Fahrleitner-Pammer Astrid
Keppel Martin
Kienreich Katharina
März Winfried
Pieske Burkert Mathias
Pilz Stefan
Schmid Johannes
Tomaschitz Andreas
Verheyen Nicolas Dominik
Wetzel Julia

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Aldosterone is considered to exert direct effects on the myocardium and the sympathetic nervous system. Both QT time and heart rate (HR) variability (HRV) are considered to be markers of arrhythmic risk and autonomous dysregulation. In this study, we investigated the associations between aldosterone, QT time, and HRV in patients with arterial hypertension.We recruited 477 hypertensive patients (age: 60.2 ± 10.2 years; 52.3% females) with a mean systolic/diastolic 24-hour ambulatory blood pressure monitoring (ABPM) value of 128 ± 12.8/77.1 ± 9.2 mmHg and with a median of 2 (IQR: 1-3) antihypertensive agents. Patients were recruited from the outpatient clinic at the Department of Internal Medicine of the Medical University of Graz, Austria. Blood samples, 24-hour HRV derived from 24-hour blood pressure monitoring (ABPM) and ECG's were obtained. Plasma aldosterone and plasma renin concentrations were measured by means of a radioimmunoassay. Twenty-four-hour urine specimens were collected in parallel with ABPM.Mean QTc was 423.3 ± 42.0 milliseconds for males and 434.7 ± 38.3 milliseconds for females. Mean 24H-HR and 24H-HRV was 71.9 ± 9.8 and 10.0 ± 3.6 bpm, respectively. In linear regression analyses adjusted for age, sex, body mass index, ABPM, and current medication, aldosterone to active renin ratio (AARR) was significantly associated with the QTc interval, a marker for cardiac repolarization abnormalities (mean = 426 ± 42.4 milliseconds; β-coefficient = 0.121; P = 0.03) as well as with the 24-hour heart rate variability a surrogate for autonomic dysfunction (median = 9.67 [IQR = 7.38-12.22 bpm]; β-coefficient = -0.133; P = 0.01).In hypertensive patients, AARR is significantly related to QTc prolongation as well as HRV. Further studies investigating the effects of mineralocorticoid receptor blocker and aldosterone synthase inhibitors on QTc and HRV are warranted.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Aged - administration & dosage
Aldosterone - blood
Austria - administration & dosage
Autonomic Nervous System Diseases - administration & dosage
Blood Pressure - physiology
Blood Pressure Monitoring, Ambulatory - administration & dosage
Electrocardiography - administration & dosage
Female - administration & dosage
Heart Rate - physiology
Humans - administration & dosage
Hypertension - drug therapy, physiopathology
Male - administration & dosage
Middle Aged - administration & dosage
Prospective Studies - administration & dosage
Radioimmunoassay - administration & dosage
Renin - blood

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