Medizinische Universität Graz - Research portal

Logo MUG Resarch Portal

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Birkl, C; Langkammer, C; Krenn, H; Goessler, W; Ernst, C; Haybaeck, J; Stollberger, R; Fazekas, F; Ropele, S.
Iron mapping using the temperature dependency of the magnetic susceptibility.
Magn Reson Med. 2015; 73(3): 1282-1288. Doi: 10.1002/mrm.25236
Web of Science PubMed FullText FullText_MUG


Leading authors Med Uni Graz
Birkl Christoph
Ropele Stefan
Co-authors Med Uni Graz
Ernst Christina
Fazekas Franz
Haybäck Johannes
Langkammer Christian
Stollberger Rudolf

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

The assessment of iron content in brain white matter (WM) is of high importance for studying neurodegenerative diseases. While R2 * mapping and quantitative susceptibility mapping is suitable for iron mapping in gray matter, iron mapping in WM still remains an unsolved problem. We propose a new approach for iron mapping, independent of diamagnetic contributions of myelin by assessing the temperature dependency of the paramagnetic susceptibility. We used unfixed human brain slices for relaxometry and calculated R2 ' as a measure for microscopic susceptibility variations at several temperatures (4°C-37°C) at 3 Tesla. The temperature coefficient of R2 ' (TcR2p) was calculated by linear regression and related to the iron concentration found by subsequent superconducting quantum interference device (SQUID) magnetometry and by inductively coupled plasma mass spectrometry. In line with SQUID measurements, R2 ' mapping showed a linear temperature dependency of the bulk susceptibility with the highest slope in gray matter. Even in WM, TcR2p yielded a high linear correlation with the absolute iron concentration. According to Curie's law, only paramagnetic matter exhibits a temperature dependency while the diamagnetism shows no effect. We have demonstrated that the temperature coefficient (TcR2p) can be used as a measure of the paramagnetic susceptibility despite of an unknown diamagnetic background. © 2014 Wiley Periodicals, Inc.

Find related publications in this database (Keywords)
magnetic susceptibility
Curie's law
Curie constant
iron quantification
iron in white matter
MRI and temperature
© Med Uni GrazImprint