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SHR Neuro Cancer Cardio Lipid Metab Microb

Stotz, M; Gerger, A; Eisner, F; Szkandera, J; Loibner, H; Ress, AL; Kornprat, P; AlZoughbi, W; Zoughbi, WA; Seggewies, FS; Lackner, C; Stojakovic, T; Samonigg, H; Hoefler, G; Pichler, M.
Increased neutrophil-lymphocyte ratio is a poor prognostic factor in patients with primary operable and inoperable pancreatic cancer.
Br J Cancer. 2013; 109(2):416-421 Doi: 10.1038/bjc.2013.332 [OPEN ACCESS]
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Leading authors Med Uni Graz
Pichler Martin
Stotz Michael
Co-authors Med Uni Graz
Al-Zoughbi Wael
Eisner Florian
Gerger Armin
Höfler Gerald
Kornprat Peter
Lackner Karoline
Lembeck Anna Lena
Samonigg Hellmut
Seggewies Friederike
Stojakovic Tatjana
Szkandera Joanna

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The neutrophil-lymphocyte ratio (NLR) has been proposed as an indicator of systemic inflammatory response. Previous findings from small-scale studies revealed conflicting results about its independent prognostic significance with regard to different clinical end points in pancreatic cancer (PC) patients. Therefore, the aim of our study was the external validation of the prognostic significance of NLR in a large cohort of PC patients. Data from 371 consecutive PC patients, treated between 2004 and 2010 at a single centre, were evaluated retrospectively. The whole cohort was stratified into two groups according to the treatment modality. Group 1 comprised 261 patients with inoperable PC at diagnosis and group 2 comprised 110 patients with surgically resected PC. Cancer-specific survival (CSS) was assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the NLR, the modified Glasgow prognostic score (mGPS) and the platelet-lymphocyte ratio univariate and multivariate Cox regression models were applied. Multivariate analysis identified increased NLR as an independent prognostic factor for inoperable PC patients (hazard ratio (HR)=2.53, confidence interval (CI)=1.64-3.91, P<0.001) and surgically resected PC patients (HR=1.61, CI=1.02-2.53, P=0.039). In inoperable PC patients, the mGPS was associated with poor CSS only in univariate analysis (HR=1.44, CI=1.04-1.98). Risk prediction for cancer-related end points using NLR does add independent prognostic information to other well-established prognostic factors in patients with PC, regardless of the undergoing therapeutic modality. Thus, the NLR should be considered for future individual risk assessment in patients with PC.
Find related publications in this database (using NLM MeSH Indexing)
Adenocarcinoma - blood Adenocarcinoma - diagnosis Adenocarcinoma - mortality Adenocarcinoma - surgery
Adult -
Aged -
Aged, 80 and over -
Cohort Studies -
Female -
Humans -
Leukocyte Count -
Lymphocytes - pathology
Male -
Middle Aged -
Neutrophils - pathology
Pancreatectomy -
Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - mortality Pancreatic Neoplasms - surgery
Prognosis -
Retrospective Studies -
Survival Analysis -

Find related publications in this database (Keywords)
pancreatic cancer
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