Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Adams, HH; Cavalieri, M; Verhaaren, BF; Bos, D; van der Lugt, A; Enzinger, C; Vernooij, MW; Schmidt, R; Ikram, MA.
Rating Method for Dilated Virchow-Robin Spaces on Magnetic Resonance Imaging.
Stroke. 2013; 44(6):1732-1735
Doi: 10.1161/STROKEAHA.111.000620
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- Co-authors Med Uni Graz
- Cavalieri Margherita
- Enzinger Christian
- Schmidt Reinhold
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- Abstract:
- Background and Purpose-Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization. Methods-We developed a rating method for dilated Virchow-Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra- and interrater reliability. Results-Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, >0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, >0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6-0.8). This did not differ between the cohorts or experience levels. Conclusions-We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow-Robin spaces using MRI.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Basal Ganglia - pathology
- Brain - pathology
- Cerebrovascular Disorders - pathology
- Cognition Disorders - pathology
- Dementia - pathology
- Extracellular Fluid -
- Female -
- Hippocampus - pathology
- Humans -
- Magnetic Resonance Imaging - methods
- Male -
- Mesencephalon - pathology
- Middle Aged -
- Observer Variation -
- Prognosis -
- Reproducibility of Results -
- Severity of Illness Index -
- Find related publications in this database (Keywords)
- epidemiology
- MRI
- population-based study
- Virchow-Robin spaces