Medizinische Universit├Ąt Graz - Research portal

Logo MUG Resarch Portal

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Adams, HH; Cavalieri, M; Verhaaren, BF; Bos, D; van der Lugt, A; Enzinger, C; Vernooij, MW; Schmidt, R; Ikram, MA.
Rating Method for Dilated Virchow-Robin Spaces on Magnetic Resonance Imaging.
Stroke. 2013; 44(6):1732-1735 Doi: 10.1161/STROKEAHA.111.000620 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG


Co-authors Med Uni Graz
Cavalieri Margherita
Enzinger Christian
Schmidt Reinhold

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Background and Purpose-Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization. Methods-We developed a rating method for dilated Virchow-Robin spaces in 4 brain regions (centrum semiovale, basal ganglia, hippocampus, and mesencephalon) and tested its reliability in a total of 125 MRI scans from 2 population-based studies. Six investigators with varying levels of experience performed the ratings. Intraclass correlation coefficients were calculated to determine intra- and interrater reliability. Results-Intrarater reliability was excellent for all 4 regions (intraclass correlation coefficient, >0.8). Interrater reliability was excellent for the centrum semiovale and hippocampus (intraclass correlation coefficient, >0.8) and good for the basal ganglia and mesencephalon (intraclass correlation coefficient, 0.6-0.8). This did not differ between the cohorts or experience levels. Conclusions-We describe a reliable rating method that can facilitate pathogenic and prognostic research on dilated Virchow-Robin spaces using MRI.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Basal Ganglia - pathology
Brain - pathology
Cerebrovascular Disorders - pathology
Cognition Disorders - pathology
Dementia - pathology
Extracellular Fluid -
Female -
Hippocampus - pathology
Humans -
Magnetic Resonance Imaging - methods
Male -
Mesencephalon - pathology
Middle Aged -
Observer Variation -
Prognosis -
Reproducibility of Results -
Severity of Illness Index -

Find related publications in this database (Keywords)
population-based study
Virchow-Robin spaces
© Med Uni GrazImprint