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Musumeci, G; Leonardi, R; Carnazza, ML; Cardile, V; Pichler, K; Weinberg, AM; Loreto, C.
Aquaporin 1 (AQP1) expression in experimentally induced osteoarthritic knee menisci: An in vivo and in vitro study.
Tissue Cell. 2013; 45(2):145-152
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Authors Med Uni Graz:
Pichler Karin
Weinberg Annelie-Martina
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Abstract:
Osteoarthritis (OA) of the knee is a major problem in our society. The development of new treatment options for OA is limited, because the pathophysiological mechanisms are not clearly understood, especially on the molecular level. Aquaporin 1 (AQP1) is a specific protein channels for water transport; it is expressed in articular chondrocytes, human synovitis, in chondrocytes of patients with rheumatoid arthritis or OA and in chondrocyte-like cells of human intervertebral disc. The aim of this study was to investigate the expression of AQP1, through immunohistochemistry, immunocytochemistry and Western blot, in experimentally induced OA knee menisci. AQP1 was studied in vivo in knee OA menisci from 36 rats that underwent medial or lateral meniscectomy, and in vitro on fibrochondrocytes derived from knee OA menisci rats. OA in rats was experimentally induced and tested by histomorphometric analysis. Histological results demonstrated structural alterations in OA menisci accompanied by a very strong AQP1 immunohistochemical and immunocytochemical staining. The Western blot analysis confirmed a strong expression of AQP1 in OA fibrochondrocytes cells. The results of the present research suggest that an activation of AQP1, induced by the OA process, may represent an endogenous mechanism, which can be used to control the tissue degeneration within OA articular joints.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Aquaporin 1 - biosynthesis
Cartilage, Articular - cytology
Chondrocytes - cytology
Gene Expression -
Humans -
Inflammation - genetics
Joints - metabolism
Knee - pathology
Menisci, Tibial - metabolism
Osteoarthritis - pathology
Rats -
Synovitis - metabolism
Water - metabolism

Find related publications in this database (Keywords)
AQP1
Knee menisci
Inflammation
Joint
Osteoarthritis
Tissue degeneration
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