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Selected Publication:

Haas, AM; Mayer, C; Haas, A; Wackernagel, W.
Effect of intravitreal C3F8 gas in patients with vitreomacular traction A retrospective case series
SPEKTRUM AUGENHEILKD. 2018; 32(6): 228-238. [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Authors Med Uni Graz:: Haas Anton; Mayer-Xanthaki Christoph; Wackernagel Werner
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Abstract:: Background We aimed to assess the efficacy of asingle intravitreal perfluoropropane (C3F8) gas injection for the treatment of vitreomacular traction with or without amacular hole. Methods In this retrospective case series, seveneyes of sixpatients with symptomatic vitreomacular traction documented on optical coherence tomography, one with amacular hole additionally, received asingle intravitreal C3F8 gas injection of up to 0.3 ml. The primary endpoint was vitreomacular traction release at 1 month after injection. Secondary endpoints included resolution of vitreomacular adhesion within 6 months, nonsurgical closure of macular holes, and change in central foveal thickness and best-corrected visual acuity. Results Overall, on optical coherence tomography, six of seven eyes (85.7%) had release of vitreomacular traction during the entire study duration: three within 1 month of injection and the other three within 6 months. Of the latter group, two of the three eyes showed aconcurrent epiretinal membrane and one concurrent diabetic retino- and maculopathy. The patient with amacular hole had resolution of vitreomacular traction within 1 month but had to undergo vitrectomy because of nonclosure of the macular hole. Associated adverse events were macular edema with aconsequent lamellar hole after injection in one patient, and another patient developed retinal detachment. Conclusion Intravitreal C(3)F(8)gas injection is an inexpensive and promising minimally invasive option for the treatment of symptomatic and persistent vitreomacular traction with or without amacular hole. Further larger studies, especially comparing C3F8 gas injection with other treatment options, are needed.
Find related publications in this database (Keywords): Intravitreal gas; Perfluoropropane (C3F8); Pneumatic vitreolysis; Vitreomacular adhesion; Vitreomacular traction