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SHR Neuro Cancer Cardio Lipid

Schwab, C; Mayer, C; Zalaudek, I; Riedl, R; Richtig, M; Wackernagel, W; Hofmann-Wellenhof, R; Richtig, G; Langmann, G; Tarmann, L; Wedrich, A; Richtig, E.
Iris Freckles a Potential Biomarker for Chronic Sun Damage.
Invest Ophthalmol Vis Sci. 2017; 58(6):BIO174-BIO179
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Authors Med Uni Graz:
Hofmann-Wellenhof Rainer
Langmann Gerald
Mayer-Xanthaki Christoph
Richtig Erika
Richtig Georg
Riedl Regina
Schwab Christoph
Vajda Lisa
Wackernagel Werner
Wedrich Andreas
Zalaudek Iris
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Abstract:
To investigate the role of sunlight exposure in iris freckles formation. We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Six hundred thirty-two participants (n = 360; 57% female) were examined. Mean age of all participants was 38.4 ± 18.4 years (range, 4-84 years). Of all individuals, 76.1% (n = 481) exhibited at least one iris freckle. Most freckles were observed in the inferior temporal quadrant. The presence of iris freckles was associated with higher age (participants with iris freckles: 41.8 ± 16.8 years versus participants without iris freckles: 27.6 ± 19.2 years), a high number of sunburns during lifetime (>10: 31% vs. 19%), sunlight-damaged skin (26% vs. 11%), presence of actinic lentigines (72% vs. 45%), and a high total nevus body count (>10; 78% vs. 67%). The association of iris freckles, behavioral factors, and dermatologic findings, as well as the topographical distribution, indicate that sunlight exposure may trigger the formation of iris freckles. The evaluation of iris freckles offers an easily accessible potential biomarker, which might be helpful in indicating sun damage on the skin associated with cutaneous malignancies. Furthermore, the evaluation of iris freckles could also be helpful in understanding the role of sunlight in several ophthalmologic diseases.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Aging - physiology
Biomarkers -
Child -
Child, Preschool -
Chronic Disease -
Eye Color -
Female -
Humans -
Iris - radiation effects
Iris Diseases - diagnosis
Iris Diseases - etiology
Male -
Melanosis - diagnosis
Melanosis - etiology
Middle Aged -
Nevus, Pigmented - diagnosis
Nevus, Pigmented - etiology
Prospective Studies -
Radiation Injuries - diagnosis
Radiation Injuries - etiology
Skin - radiation effects
Skin Neoplasms - diagnosis
Skin Neoplasms - etiology
Sunburn - complications
Sunlight - adverse effects
Surveys and Questionnaires -

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