Medizinische Universit├Ąt Graz - Research portal

Logo MUG Resarch Portal

Selected Publication:

SHR Neuro Cancer Cardio Lipid

Ewald, L; Beate, LW; Stephanie, S; Wilfried, R; Yosuf, el-S.
Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases.
J Immunol Res. 2015; 2015:174062-174062 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Authors Med Uni Graz:
El-Shabrawi Yosuf
Langner-Wegscheider Beate-Julia
Lindner Ewald
Renner Wilfried
Sarny Stephanie

Dimensions Citations:

Plum Analytics:
Interleukin 6 (IL-6) plays a crucial role in both adaptive and innate immunity. The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis. 134 patients with HLAB27 positive iridocyclitis, 84 patients with intermediate uveitis, 132 controls, and 65 HLAB27 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction. The frequency of carriers of the minor allele for rs1800795 was significantly higher in patients with intermediate uveitis compared to controls (p = 0.04; OR: 1.46; CI: 1.02-2.11). Frequencies of the minor allele for rs1800795 did not differ significantly in patients with HLAB27 associated uveitis when compared to controls (p > 0.05). These findings further deepen our understanding of the commonality between multiple sclerosis and intermediate uveitis. Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Alleles -
Autoimmunity - genetics
Capsule Opacification - genetics
Capsule Opacification - immunology
Capsule Opacification - pathology
Case-Control Studies -
Female -
Gene Expression -
Gene Frequency -
Genetic Predisposition to Disease -
Glaucoma - genetics
Glaucoma - immunology
Glaucoma - pathology
HLA-B27 Antigen - genetics
HLA-B27 Antigen - immunology
Humans -
Interleukin-6 - genetics
Interleukin-6 - immunology
Male -
Middle Aged -
Polymorphism, Single Nucleotide -
Spondylitis, Ankylosing - genetics
Spondylitis, Ankylosing - immunology
Spondylitis, Ankylosing - pathology
Uveitis, Intermediate - genetics
Uveitis, Intermediate - immunology
Uveitis, Intermediate - pathology

© Meduni GrazImprint