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Walochnik, J; Scheikl, U; Haller-Schober, EM.
Twenty years of acanthamoeba diagnostics in Austria.
J Eukaryot Microbiol. 2014; 62(1):3-11 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Authors Med Uni Graz:
Haller-Schober Eva-Maria
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Abstract:
Acanthamoebae are the causative agents of an often seriously progressing keratitis (AK) occurring predominantly in contact lens wearers and can cause several disseminating infections potentially resulting in granulomatous amoebic encephalitis (GAE) in the immunocompromised host. Our institution is the Austrian reference laboratory for Acanthamoeba diagnostics and the aim of this study was to give an overview of proven cases of Acanthamoeba infections in Austria during the past 20 yr. All samples of patients with suspected AK or GAE were screened for Acanthamoeba spp. by culture and/or PCR and the detected amoebae were genotyped. Altogether, 154 cases of AK and three cases of GAE were diagnosed. Age of the AK patients ranged from 8 to 82 yr (mean 37.8) and 58% of the patients were female. Approximately 89% of the AK patients were contact lens wearers, almost all cases were unilateral and 19% of the patients required a keratoplasty. Age of the GAE patients ranged from 2 to 25 yr (mean 14.7), all were HIV-negative, but two were severely immunosuppressed at the time of diagnosis. The predominant genotype in the AK cases was T4, other genotypes found were T3, T5, T6, T10 and T11. The three GAE cases involved genotypes T2, T4 and T5. © 2014 The Authors. The Journal of Eukaryotic Microbiology published by Wiley Periodicals, Inc. on behalf of International Society of Protistologists.
Find related publications in this database (using NLM MeSH Indexing)
Acanthamoeba - classification
Acanthamoeba - genetics
Acanthamoeba - isolation & purification
Acanthamoeba Keratitis - diagnosis
Acanthamoeba Keratitis - immunology
Acanthamoeba Keratitis - parasitology
Acanthamoeba Keratitis - surgery
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Amebiasis - diagnosis
Amebiasis - immunology
Amebiasis - parasitology
Amebiasis - surgery
Child -
Child, Preschool -
Contact Lenses - parasitology
Corneal Transplantation - methods
Encephalitis - diagnosis
Encephalitis - immunology
Encephalitis - parasitology
Encephalitis - surgery
Female -
Genotype -
Humans -
Immunocompromised Host -
Male -
Middle Aged -

Find related publications in this database (Keywords)
characterisation
contact lens
infection
protozoa
SSU
typing
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