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Weger, M; Steinbrugger, I; Renner, W; Pöschl, EM; Brockmann, T; Rabensteiner, DF; El-Shabrawi, Y; Haas, A.
Role of the vitamin K epoxide reductase complex subunit 1 (VKORC1) -1639G>A gene polymorphism in patients with retinal vein occlusion.
Curr Eye Res. 2013; 38(12):1278-1282
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Authors Med Uni Graz:
El-Shabrawi Yosuf
Haas Anton
Malle Eva Maria
Rabensteiner Dieter
Renner Wilfried
Steinbrugger Iris
Weger Martin
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Abstract:
Retinal vein occlusion (RVO) is a major vision-threatening disease. Vitamin K epoxide reductase recycles reduced vitamin K, which is essential for the gamma carboxylation of clotting factors II, VII, IX, X and proteins C and S. Recently, the vitamin K epoxide reductase complex subunit 1 (VKORC1) -1639G>A (rs9923231) polymorphism has been reported as a novel risk factor for RVO in a Turkish population. The present study was set to confirm or to refute this association in a larger cohort of patients with RVO. The present case-control study comprised 285 patients with central RVO, 401 patients with branch RVO and 333 control subjects. Genotypes of the VKORC1 -1639G>A polymorphism were determined by 5' exonuclease assay (TaqMan). No significant differences in either genotype distributions or allele frequencies of the vitamin K epoxide reductase complex subunit 1 -1639G>A polymorphism were found between patients and control subjects (p > 0.05). In a logistic regression analysis neither branch nor central RVO was predicted by the vitamin K epoxide reductase complex subunit 1 -1639G>A genotypes, but by arterial hypertension, ever-smoking status and in case of central RVO additionally by diabetes mellitus. Our data suggest that the vitamin K epoxide reductase complex subunit 1 -1639G>A gene polymorphism is unlikely a major risk factor for patients with either central or branch RVO.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Case-Control Studies -
Female -
Genetic Predisposition to Disease - epidemiology
Genotype -
Humans -
Logistic Models -
Male -
Middle Aged -
Polymorphism, Single Nucleotide -
Retinal Vein Occlusion - epidemiology
Risk Factors -
Vitamin K - metabolism
Vitamin K Epoxide Reductases - genetics

Find related publications in this database (Keywords)
Branch retinal vein occlusion
central retinal vein occlusion
genetics
risk factors
VKORC1
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