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Langner-Wegscheider, BJ; ten Dam-van Loon, N; Mura, M; Faridpooya, K; de Smet, MD.
Intravitreal ganciclovir in the management of non-AIDS-related human cytomegalovirus retinitis.
CAN J OPHTHALMOL-J CAN OPHTAL. 2010; 45(2): 157-160.
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Authors Med Uni Graz:
Langner-Wegscheider Beate-Julia
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Abstract:
Objective: To report and evaluate intravitreal ganciclovir injections in non-AIDS patients with human cytomegalovirus (HCMV) retinitis. Design: Retrospective chart review. Participants: Two SLE patients and one patient post chemotherapy for a non Hodgkin's lymphoma presented with myelosuppression and persistent cytomegalovirus retinitis despite systemic ganciclovir therapy. Methods: Patients were treated with 100 mu L of intravitreal ganciclovir (4 mg/dL), initially given weekly. Systemic anti-CMV medication was stopped, and following quiescence, intravitreal injections were tapered and ultimately stopped based on therapeutic response. Patients were followed periodically for signs of recurrence. Results: Intravitreal ganciclovir was well tolerated and led to remission of the retinitis in 2 patients. One patient had persistent smouldering disease and reached quiescence using an intravitreal ganciclovir implant. Fluorescence-activated cell sorting analysis in one patient showed the presence of low CD4 and CD8 while treated with systemic ganciclovir, which improved with intravitreal treatment. In another, the low ratio was maintained against cytomegalovirus-specific antigens. Conclusions: Intravitreal ganciclovir injections should be considered as a treatment option in selected iatrogenically immunocompromised patients with HCMV retinitis. Responses may vary and will require an adjusted approach to treatment.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Antiviral Agents - administration and dosage
CD4 Lymphocyte Count -
CD4-CD8 Ratio -
Cytomegalovirus Retinitis - drug therapy
Female -
Flow Cytometry -
Ganciclovir - administration and dosage
HIV Seronegativity -
Humans -
Injections -
Middle Aged -
Retrospective Studies -
Treatment Outcome -
Vitreous Body -

Find related publications in this database (Keywords)
CMV retinitis
intravitreal ganciclovir
non-AIDS patients
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