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Chauhan, G; Adams, HHH; Bis, JC; Weinstein, G; Yu, L; Töglhofer, AM; Smith, AV; van der Lee, SJ; Gottesman, RF; Thomson, R; Wang, J; Yang, Q; Niessen, WJ; Lopez, OL; Becker, JT; Phan, TG; Beare, RJ; Arfanakis, K; Fleischman, D; Vernooij, MW; Mazoyer, B; Schmidt, H; Srikanth, V; Knopman, DS; Jack, CR; Amouyel, P; Hofman, A; DeCarli, C; Tzourio, C; van Duijn, CM; Bennett, DA; Schmidt, R; Longstreth, WT; Mosley, TH; Fornage, M; Launer, LJ; Seshadri, S; Ikram, MA; Debette, S.
Association of Alzheimer's disease GWAS loci with MRI markers of brain aging.
Neurobiol Aging. 2015; 36(4):1765.e7-1761765 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Authors Med Uni Graz:
Birkl-Töglhofer Anna Maria
Schmidt Helena
Schmidt Reinhold
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Abstract:
Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N = 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (p = 0.0054) and CD33 (rs3865444) with smaller intracranial volume (p = 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (p = 0.0006) and BIN1 with HV (p = 0.00089). A weighted AD genetic risk score was associated with smaller HV (beta ± SE = -0.047 ± 0.013, p = 0.00041), even after excluding the APOE locus (p = 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons. Copyright © 2015 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aging - genetics
Aging - pathology
Alleles -
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Apolipoproteins E - genetics
Brain - pathology
Female -
Genome-Wide Association Study -
Hippocampus - pathology
Humans -
Magnetic Resonance Imaging -
Male -
Organ Size - genetics
Polymorphism, Single Nucleotide -
Risk -
Sialic Acid Binding Ig-like Lectin 3 - genetics

Find related publications in this database (Keywords)
Alzheimer
MRI-Markers
Genetic risk score
GWAS
Hippocampal volume
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