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SHR Neuro Cancer Cardio Lipid

Terbuch, A; Posch, F; Bauernhofer, T; Pichler, M; Peinsith, H; Szkandera, J; Riedl, J; Hutterer, GC; Pummer, K; Partl, R; Kapp, KS; Stöger, H; Stotz, M; Gerger, A.
Age as a Predictor of Treatment Outcome in Metastatic Testicular Germ Cell Tumors.
Anticancer Res. 2019; 39(10):5589-5596
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Authors Med Uni Graz:
Bauernhofer Thomas
Gerger Armin
Hutterer Georg C.
Kapp Karin S.
Partl Richard
Pichler Martin
Posch Florian
Pummer Karl
Riedl Jakob
Stoeger Herbert
Stotz Michael
Szkandera Joanna
Terbuch Angelika
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Abstract:
To quantify the prognostic impact of age on relapse and mortality in patients with metastatic testicular germ cell tumors (TGCT). Electronical medical records of 1,225 TGCT patients who were treated at a single academic center between 1994 and 2015 were reviewed. Higher age did not predict for worse progression-free survival (PFS) or for higher progression risk. The corresponding 5-year PFS estimates were 85% in patients younger than 40 years and 83% in the elderly population. Although not statistically significant, higher age was numerically associated with worse overall survival (OS) (univariate HR per five years increase in age=1.18, 95%CI=0.99-1.41). This was explained in regression analysis where age predicted for significantly higher risk of treatment-related death (p=0.022). Elderly patients with metastatic TGCT can achieve high cure rates similar to younger patients if they tolerate risk-adapted chemotherapy. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Age Factors -
Disease Progression -
Humans -
Male -
Neoplasms, Germ Cell and Embryonal - drug therapy
Neoplasms, Germ Cell and Embryonal - pathology
Prognosis -
Progression-Free Survival -
Recurrence -
Retrospective Studies -
Risk Factors -
Testicular Neoplasms - drug therapy
Testicular Neoplasms - pathology
Treatment Outcome -

Find related publications in this database (Keywords)
Age
testicular cancer
germ cell tumors
prognosis
outcome
chemotherapy
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