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SHR Neuro Cancer Cardio Lipid

Czapiewski, P; Gorczynski, A; Radecka, K; Wiewiora, C; Haybaeck, J; Adam, P; Fend, F; Zakrzewska, M; Zakrzewski, K; Liberski, PP; Biernat, W.
Expression of SOX11, PAX5, TTF-1 and ISL-1 in medulloblastoma.
Pathol Res Pract. 2016; 212(11):965-971
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Authors Med Uni Graz:
Haybäck Johannes
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Abstract:
The aim of our study was to evaluate the immunohistochemical expression of SOX11, PAX5, TTF-1 and ISL-1 in medulloblastoma (MB) to investigate their diagnostic usefulness. Immunohistochemical expression of PAX5 (two antibodies: Dako, DAK-Pax5; and BD, clone 24), TTF-1 (Dako, 8G7G3/1), SOX11 (CL0142; Abcam) and ISL-1 (1 H9, Abcam) was analyzed using the h-score and Remmele score in 25 cases of MB. There were 18 MBs of classic and 7 of desmoplastic type. SOX11 was strongly expressed in all tumors. The expression of PAX5 was higher and more frequent in a case of DAK-Pax5 clone (25/25) than clone 24 (6/25). ISL-1 was positive in 11 (44%) and TTF-1 in 3 (12%) cases. ISL-1 expression correlated positively (p<0.001), while TTF-1 correlated negatively with the age of patients (p=0.039). PAX5 expression correlated with ISL-1 (p=0.039) and showed a trend toward higher expression in the desmoplastic subtype (p=0.069). SOX11 is strongly and robustly expressed in MBs. PAX5 expression pattern differs substantially among two antibody clones. TTF-1 and ISL-1 is associated with the age of patients. Copyright © 2016 Elsevier GmbH. All rights reserved.
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Adolescent -
Adult -
Biomarkers, Tumor - analysis
Cerebellar Neoplasms - diagnosis
Cerebellar Neoplasms - metabolism
Child -
Child, Preschool -
DNA-Binding Proteins - analysis
DNA-Binding Proteins - biosynthesis
Female -
Humans -
Immunohistochemistry -
Infant -
LIM-Homeodomain Proteins - analysis
LIM-Homeodomain Proteins - biosynthesis
Male -
Medulloblastoma - diagnosis
Medulloblastoma - metabolism
PAX5 Transcription Factor - analysis
PAX5 Transcription Factor - biosynthesis
SOXC Transcription Factors - analysis
SOXC Transcription Factors - biosynthesis
Transcription Factors - analysis
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SOX11
PAX5
TTF-1
ISL-1
Medulloblastoma
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