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SHR Neuro Cancer Cardio Lipid

Zaloga, J; Pöttler, M; Leitinger, G; Friedrich, RP; Almer, G; Lyer, S; Baum, E; Tietze, R; Heimke-Brinck, R; Mangge, H; Dörje, F; Lee, G; Alexiou, C.
Pharmaceutical formulation of HSA hybrid coated iron oxide nanoparticles for magnetic drug targeting.
Eur J Pharm Biopharm. 2016; 101(3):152-162
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Authors Med Uni Graz:
Almer Gunter
Leitinger Gerd
Mangge Harald

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In this work we present a new formulation of superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic drug targeting. The particles were reproducibly synthesized from current good manufacturing practice (cGMP) - grade substances. They were surface coated using fatty acids as anchoring molecules for human serum albumin. We comprehensively characterized the physicochemical core-shell structure of the particles using sophisticated methods. We investigated biocompatibility and cellular uptake of the particles using an established flow cytometric method in combination with microwave-plasma assisted atomic emission spectroscopy (MP-AES). The cytotoxic drug mitoxantrone was adsorbed on the protein shell and we showed that even in complex media it is slowly released with a close to zero order kinetics. We also describe an in vitro proof-of-concept assay in which we clearly showed that local enrichment of this SPION-drug conjugate with a magnet allows site-specific therapeutic effects. Copyright © 2016. Published by Elsevier B.V.
Find related publications in this database (using NLM MeSH Indexing)
Biocompatible Materials - chemistry
Cell Line, Tumor -
Chemistry, Pharmaceutical - methods
Drug Delivery Systems -
Ferric Compounds - chemistry
Humans -
Jurkat Cells -
Magnetics - methods
Microscopy, Atomic Force - methods
Mitoxantrone - chemistry
Nanoparticles - chemistry
Serum Albumin - chemistry

Find related publications in this database (Keywords)
Superparamagnetic iron oxide nanoparticles
Good manufacturing practice
Magnetic drug targeting
Human serum albumin
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