Medizinische Universität Graz - Research portal
Selected Publication:
Hermann, J; Mueller, T; Fahrleitner, A; Dimai, HP.
Early onset and effective inhibition of bone resorption in patients with rheumatoid arthritis treated with the tumour necrosis factor alpha antibody infliximab.
CLIN EXP RHEUMATOL 2003 21: 473-476.
Web of Science
PubMed
- Leading authors Med Uni Graz
- Hermann Josef
- Co-authors Med Uni Graz
- Dimai Hans Peter
- Fahrleitner-Pammer Astrid
- Müller Thomas
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- Abstract:
- OBJECTIVE: To investigate the effect of the tumour necrosis factor alpha antibody infliximab on bone metabolism in patients with rheumatoid arthritis (RA). METHODS: Twelve RA patients with active disease on a constant dose of methotrexate were treated with a single infusion of infliximab (10 mg/kg BW). Serum beta-CrossLaps and serum osteocalcin as markers of bone resorption and formation were measured two days and one day before and one and 14 days after infliximab infusion with an electrochemiluminiscence immunoassay. RA disease activity was determined using the Disease Activity Score (DAS) and the ACR-response criteria. RESULTS: Infliximab treatment significantly reduced serum beta-CrossLaps levels from 0.29 +/- 0.13 (mean +/- SD) ng/ml at study entry to 0.17 +/- 0.09 pg/ml one day after infusion (p < 0.005). At day 14 serum beta-CrossLaps levels were still significantly lower compared to pre-treatment levels (0.24 +/- 0.13 pg/ml, p < 0.05). In contrast, serum osteocalcin levels remained unchanged during the observation period (17.8 +/- 9.8 vs 18.2 +/- 9.9 vs 18.6 +/- 12.1 ng/ml, respectively). All but one patient improved clinically after infliximab infusion and the DAS dropped significantly from 6.5 +/- 0.9 prior to treatment to 5.8 +/- 1.3 and 5.0 +/- 1.3 at Day one and 14 days after treatment, respectively. Four patients showed an ACR 20-response one day after therapy and 10 patients 14 days after therapy. CONCLUSION: Infliximab might have potential to inhibit generalised bone loss in patients with RA in addition to its clinical efficacy in reducing disease activity and inhibiting joint destruction.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Antibodies, Monoclonal - therapeutic use
- Arthritis, Rheumatoid - diagnosis
- Bone Resorption - drug therapy
- Comparative Study - drug therapy
- Dose-Response Relationship, Drug - drug therapy
- Female - drug therapy
- Follow-Up Studies - drug therapy
- Humans - drug therapy
- Infusions, Intravenous - drug therapy
- Male - drug therapy
- Methotrexate - administration and dosage
- Middle Aged - administration and dosage
- Probability - administration and dosage
- Prospective Studies - administration and dosage
- Sensitivity and Specificity - administration and dosage
- Severity of Illness Index - administration and dosage
- Statistics, Nonparametric - administration and dosage
- Treatment Outcome - administration and dosage
- Find related publications in this database (Keywords)
- rheumatoid arthritis
- infliximab
- bone resorption
- TNF alpha