Medizinische Universität Graz - Research portal
Selected Publication:
Haas, A; Pinter, O; Papaefthymiou, G; Weger, M; Berghold, A; Schröttner, O; Müllner, K; Pendl, G; Langmann, G.
Incidence of radiation retinopathy after high-dosage single-fraction gamma knife radiosurgery for choroidal melanoma.
OPHTHALMOLOGY 2002 109: 909-913.
Doi: 10.1016%2FS0161-6420%2802%2901011-4
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Haas Anton
- Co-authors Med Uni Graz
- Berghold Andrea
- Langmann Gerald
- Papaefthymiou Georgios
- Schroettner Oskar
- Weger Martin
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVE: To investigate the incidence and clinical findings of radiation retinopathy after single-fraction high-dose gamma knife radiosurgery for choroidal melanoma. DESIGN: Retrospective noncomparative interventional case series. PARTICIPANTS: Thirty-two patients with choroidal melanoma. METHODS: Review of charts, color fundus photographs, and fluorescein angiograms of 32 choroidal melanoma patients after radiosurgery. All patients were treated with the Leksell gamma knife in one fraction with a marginal dose between 40 and 80 Gy (median, 50 Gy) and were followed for at least 24 months (or until enucleation because of complications secondary to radiation). MAIN OUTCOME MEASURES: Any clinical feature of radiation retinopathy and neovascular glaucoma. RESULTS: During a mean follow-up of 38 months (range, 6-81 months) we found radiation retinopathy in 84% of our patients. The most common findings in these patients were intraretinal hemorrhages with an incidence of 70%, macular edema and capillary nonperfusion in 63%, and hard exudates in 52% of the patients. Less common were microaneurysms in 30% and retinal neovascularization in 22%. The time of onset of the various radiation-associated retinal findings ranged between 1 and 22 months. Forty-seven percent of all patients developed neovascular glaucoma. In our study there was no correlation between radiation dosage applied and clinical findings. CONCLUSIONS: Single-fraction high-dose Leksell gamma knife radiosurgery of choroidal melanomas with a median marginal dose of 50 Gy is highly associated with early radiation retinopathy and with neovascular glaucoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Choroid Neoplasms - surgery
- Female - surgery
- Fluorescein Angiography - surgery
- Follow-Up Studies - surgery
- Glaucoma, Neovascular - epidemiology
- Humans - epidemiology
- Incidence - epidemiology
- Male - epidemiology
- Melanoma - surgery
- Middle Aged - surgery
- Radiation Injuries - epidemiology
- Radiosurgery - adverse effects
- Retina - radiation effects
- Retinal Diseases - epidemiology
- Retrospective Studies - epidemiology