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Suppan, E; Urlesberger, B; Schwaberger, B; Höller, N; Wolfsberger, CH; Avian, A; Pichler, G.
Fetal Hemoglobin and Cerebral Tissue Oxygenation during Immediate Postnatal Transition.
Neonatology. 2022; 119(5):602-610 Doi: 10.1159/000525847
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Leading authors Med Uni Graz
Pichler Gerhard
Suppan Ena
Co-authors Med Uni Graz
Avian Alexander
Höller Nina
Schwaberger Bernhard Christian
Urlesberger Berndt
Wolfsberger Christina H.

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INTRODUCTION: Concentration of fetal hemoglobin (HbFc) in human neonates determines oxygen-carrying capacity of blood and the position of oxyhemoglobin dissociation curve. Near-infrared spectroscopy enables the measurement of regional cerebral tissue oxygen saturation (rScO2) and in combination with measurements of pulsatile arterial oxygen saturation (SpO2), the calculation of cerebral fractional tissue oxygen extraction (cFTOE). METHODS: We aimed to investigate the impact of HbFc on rScO2, cFTOE, and SpO2 in preterm and term neonates during the first 15 min after birth. Blood analyses provided total blood hemoglobin (Hb) and HbFc measurements. Correlations between HbFc, Hb and rScO2, cFTOE, and SpO2 in each minute were analyzed. RESULTS: Ninety term and 19 preterm neonates without medical support were included. HbFc was significantly higher in preterm neonates, whereas there were no significant differences in Hb between the groups. In preterm neonates, we found positive correlations of both HbFc and Hb with rScO2 and negative correlations of HbFc and Hb with cFTOE in the first minutes after birth. In contrast, there were no significant correlations between the same parameters in term neonates. Correlations between HbFc or Hb and SpO2 were either insignificant, negligible, or very low in both groups. DISCUSSION/CONCLUSION: In preterm neonates, higher HbFc was associated with higher rScO2 and lower cFTOE in the first minutes after birth. This phenomenon could not be confirmed in term neonates and might reflect immature autoregulation of oxygen delivery to the brain or lower oxygen consumption in preterm neonates in the first minutes of immediate postnatal transition.
Find related publications in this database (using NLM MeSH Indexing)
Brain - administration & dosage
Cerebrovascular Circulation - physiology
Fetal Hemoglobin - analysis
Humans - administration & dosage
Infant, Newborn - administration & dosage
Infant, Premature - physiology
Oximetry - administration & dosage
Oxygen - administration & dosage
Oxyhemoglobins - analysis

Find related publications in this database (Keywords)
Fetal hemoglobin
Postnatal transition
Near-infrared spectroscopy
Regional cerebral tissue oxygen saturation
Cerebral fractional tissue oxygen extraction
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