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SHR Neuro Cancer Cardio Lipid Metab Microb

Kvietkauskas, M; Zitkute, V; Leber, B; Strupas, K; Stiegler, P; Schemmer, P.
The role of melatonin in colorectal cancer treatment: a comprehensive review.
Ther Adv Med Oncol. 2020; 12(9):1758835920931714-1758835920931714 Doi: 10.1177/1758835920931714 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Stiegler Philipp
Co-authors Med Uni Graz: Leber Bettina; Schemmer Peter
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Abstract:: Colorectal cancer (CRC) is one of the most common types of cancer worldwide, known as the second leading cause of cancer-related deaths annually. Currently, multimodal treatment strategies, including surgical resection, combined with chemotherapy and radiotherapy, have been used as conventional treatments in patients with CRC. However, clinical outcome of advanced stage disease remains relatively discouraging, due mainly to appearance of CRC chemoresistance, toxicity, and other detrimental side effects. New strategies to overcome these limitations are essential. During the last decades, melatonin (MLT) has been shown to be a potent antiproliferative, anti-metastatic agent with cytotoxic effects on different types of human malignancies, including CRC. Hence, this comprehensive review compiles the available experimental and clinical data analyzing the effects of MLT treatment in CRC patients and its underlying molecular mechanisms. © The Author(s), 2020.
Find related publications in this database (Keywords): anticancer drug combinations; colorectal cancer; melatonin; review