Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Platzer, M; Fellendorf, FT; Bengesser, SA; Birner, A; Dalkner, N; Hamm, C; Hartleb, R; Queissner, R; Pilz, R; Rieger, A; Maget, A; Mangge, H; Zelzer, S; Reininghaus, B; Kapfhammer, HP; Reininghaus, EZ.
Adiponectin is decreased in bipolar depression.
World J Biol Psychiatry. 2019; 20(10):813-820
Doi: 10.1080/15622975.2018.1500033
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Fellendorf Frederike
- Platzer Martina
- Co-authors Med Uni Graz
- Bengesser Susanne
- Birner Armin
- Dalkner Nina
- Hamm Carlo
- Hartleb Riccarda
- Kapfhammer Hans-Peter
- Maget Alexander
- Mangge Harald
- Pilz Rene
- Queissner Robert
- Reininghaus Bernd
- Reininghaus Eva
- Rieger Alexandra
- Zelzer Sieglinde
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- Abstract:
- Objectives: Bipolar disorder (BD) is often accompanied by medical comorbidities, which affect illness course and prognosis. Adipokines may not only be involved in the aetiopathogenetic mechanisms of these comorbidities; there might be an association between adipokines and the neuropsychiatric core features of BD such as mood disturbances and cognitive deficits.Methods: In this investigation, fasting blood samples from 120 individuals with BD (75 euthymic and 45 with mild depressive symptoms) and 68 control subjects were taken and adiponectin and leptin concentrations were analysed.Results: We found that, in female participants, adiponectin levels differed significantly between patients and controls indicating lower levels in individuals with BD, even after controlling for BMI (F(1,92) = 4.65, P = 0.034, partial η2 = 0.05). After stratification by mood status we found a significant difference in adiponectin between controls, euthymic and depressive patients (F(2, 180) = 4.90, P = 0.008, partial η2 = 0.05).Conclusions: This investigation confirms previous findings of an association between low adiponectin levels and depressive state in individuals with BD. Beyond its immediate effect on central nervous system function, adiponectin might interfere with pathophysiological mechanisms of BD and its somatic comorbidities via involvement in metabolic and inflammatory processes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adiponectin - blood
- Adult - administration & dosage
- Bipolar Disorder - blood, physiopathology
- Case-Control Studies - administration & dosage
- Comorbidity - administration & dosage
- Disease Progression - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Leptin - blood
- Male - administration & dosage
- Middle Aged - administration & dosage
- Obesity - blood
- Find related publications in this database (Keywords)
- Bipolar disorder
- adipokines
- adiponectin
- leptin
- obesity