Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wang, JY; Chen, R; Chen, SP; Gao, YH; Zhang, JL; Feng, XM; Yan, Y; Liu, JL; Gaischek, I; Litscher, D; Wang, L; Lippe, IT; Litscher, G.
Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats.
Neural Plast. 2016; 2016(51):6521026-6521026
Doi: 10.1155/2016/6521026
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Web of Science
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- Leading authors Med Uni Graz
- Litscher Gerhard
- Co-authors Med Uni Graz
- Gaischek Ingrid
- Lippe Irmgard
- Litscher Daniela
- Wang Lu
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- Abstract:
- To study the effects of acupuncture analgesia on the hippocampus, we observed the effects of electroacupuncture (EA) and mitogen-activated protein kinase (MEK) inhibitor on pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the hippocampal area CA1 of sham or chronic constrictive injury (CCI) rats. The animals were randomly divided into a control, a CCI, and a U0126 (MEK1/2 inhibitor) group. In all experiments, we briefly (10-second duration) stimulated the sciatic nerve electrically and recorded the firing rates of PENs and PINs. The results showed that in both sham and CCI rats brief sciatic nerve stimulation significantly increased the electrical activity of PENs and markedly decreased the electrical activity of PINs. These effects were significantly greater in CCI rats compared to sham rats. EA treatment reduced the effects of the noxious stimulus on PENs and PINs in both sham and CCI rats. The effects of EA treatment could be inhibited by U0126 in sham-operated rats. The results suggest that EA reduces effects of acute sciatic nerve stimulation on PENs and PINs in the CA1 region of the hippocampus of both sham and CCI rats and that the ERK (extracellular regulated kinase) signaling pathway is involved in the modulation of EA analgesia.
- Find related publications in this database (using NLM MeSH Indexing)
- Acupuncture Analgesia - methods
- Animals -
- Disease Models, Animal -
- Electroacupuncture - methods
- Hippocampus - metabolism
- Male -
- Mitogen-Activated Protein Kinases - metabolism
- Neuralgia - metabolism
- Neuralgia - therapy
- Neurons - metabolism
- Rats, Wistar -
- Sciatic Nerve - injuries
- Sciatic Nerve - physiopathology
- Sciatic Neuropathy - metabolism
- Sciatic Neuropathy - physiopathology