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SHR Neuro Cancer Cardio Lipid Metab Microb

Horvath, A; Leber, B; Schmerboeck, B; Tawdrous, M; Zettel, G; Hartl, A; Madl, T; Stryeck, S; Fuchs, D; Lemesch, S; Douschan, P; Krones, E; Spindelboeck, W; Durchschein, F; Rainer, F; Zollner, G; Stauber, RE; Fickert, P; Stiegler, P; Stadlbauer, V.
Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis.
Aliment Pharmacol Ther. 2016; 44(9):926-935 Doi: 10.1111/apt.13788 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Leading authors Med Uni Graz
Horvath Angela
Leber Bettina
Co-authors Med Uni Graz
Baumann-Durchschein Franziska
Douschan Philipp
Fickert Peter
Lemesch Sandra
Madl Tobias
Rainer Florian
Spindelböck Walter Johann
Stadlbauer-Köllner Vanessa
Stauber Rudolf
Stiegler Philipp
Stryeck Sarah
Tatscher Elisabeth
Tawdrous Monika
Zettel Gabriele
Zollner Gernot

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Probiotics may correct intestinal dysbiosis and proinflammatory conditions in patients with liver cirrhosis. To test the effects of a multispecies probiotic on innate immune function, bacterial translocation and gut permeability. In a randomised, double blind, placebo-controlled study, stable cirrhotic out-patients either received a daily dose of a probiotic powder containing eight different bacterial strains (Ecologic Barrier, Winclove, Amsterdam, The Netherlands) (n = 44) or a placebo (n = 36) for 6 months and were followed up for another 6 months. We found a significant but subclinical increase in neutrophil resting burst (2.6-3.2%, P = 0.0134) and neopterin levels (7.7-8.4 nmol/L, P = 0.001) with probiotics but not with placebo. Probiotic supplementation did not have a significant influence on neutrophil phagocytosis, endotoxin load, gut permeability or inflammatory markers. Ten severe infections occurred in total; one during intervention in the placebo group, and five and four after the intervention has ended in the probiotic and placebo group, respectively. Liver function showed some improvement with probiotics but not with placebo. Probiotic supplementation significantly increased serum neopterin levels and the production of reactive oxygen species by neutrophils. These findings might explain the beneficial effects of probiotics on immune function. Furthermore, probiotic supplementation may be a well-tolerated method to maintain or even improve liver function in stable cirrhosis. However, its influence on gut barrier function and bacterial translocation in cirrhotic patients is minimal. © 2016 The Authors. Alimentary Pharmacology & Therapeutics Published by John Wiley & Sons Ltd.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Bacterial Translocation - drug effects
Bacterial Translocation - physiology
Dietary Supplements -
Double-Blind Method -
Female -
Gastrointestinal Absorption - drug effects
Gastrointestinal Absorption - physiology
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - physiology
Humans -
Immunity, Innate - drug effects
Immunity, Innate - physiology
Liver Cirrhosis - drug therapy
Liver Cirrhosis - immunology
Liver Cirrhosis - microbiology
Male -
Middle Aged -
Permeability - drug effects
Probiotics - administration & dosage
Treatment Outcome -

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