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Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Al-Zoughbi, W; Pichler, M; Gorkiewicz, G; Guertl-Lackner, B; Haybaeck, J; Jahn, SW; Lackner, C; Liegl-Atzwanger, B; Popper, H; Schauer, S; Nusshold, E; Kindt, AS; Trajanoski, Z; Speicher, MR; Haemmerle, G; Zimmermann, R; Zechner, R; Vesely, PW; Hoefler, G.
Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.
Oncotarget. 2016; 7(23):33832-33840 Doi: 10.18632/oncotarget.9418 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Leading authors Med Uni Graz
Al-Zoughbi Wael
Höfler Gerald
Vesely Paul
Co-authors Med Uni Graz
Gorkiewicz Gregor
Gürtl-Lackner Barbara
Haybäck Johannes
Jahn Stephan
Lackner Karoline
Liegl-Atzwanger Bernadette
Nußhold Elisa
Pichler Martin
Popper Helmuth
Schauer Silvia
Speicher Michael

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Scite (citation analytics):

Metabolic reprogramming is a hallmark of cancer. Understanding cancer metabolism is instrumental to devise innovative therapeutic approaches. Anabolic metabolism, including the induction of lipogenic enzymes, is a key feature of proliferating cells. Here, we report a novel tumor suppressive function for adipose triglyceride lipase (ATGL), the rate limiting enzyme in the triglyceride hydrolysis cascade.In immunohistochemical analysis, non-small cell lung cancers, pancreatic adenocarcinoma as well as leiomyosarcoma showed significantly reduced levels of ATGL protein compared to corresponding normal tissues. The ATGL gene was frequently deleted in various forms of cancers. Low levels of ATGL mRNA correlated with significantly reduced survival in patients with ovarian, breast, gastric and non-small cell lung cancers. Remarkably, pulmonary neoplasia including invasive adenocarcinoma developed spontaneously in mice lacking ATGL pointing to an important role for this lipase in controlling tumor development.Loss of ATGL, as detected in several forms of human cancer, induces spontaneous development of pulmonary neoplasia in a mouse model. Our results, therefore, suggest a novel tumor suppressor function for ATGL and contribute to the understanding of cancer metabolism. We propose to evaluate loss of ATGL protein expression for the diagnosis of malignant tumors. Finally, modulation of the lipolytic pathway may represent a novel therapeutic approach in the treatment of human cancer.
Find related publications in this database (using NLM MeSH Indexing)
Adenocarcinoma - enzymology
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Adenocarcinoma of Lung -
Animals -
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Computational Biology -
Data Mining -
Databases, Genetic -
Down-Regulation -
Gene Expression Regulation, Enzymologic -
Gene Expression Regulation, Neoplastic -
Genetic Predisposition to Disease -
Humans -
Lipase - analysis
Lipase - deficiency
Lipase - genetics
Lipolysis -
Lung Neoplasms - enzymology
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Mice, Inbred C57BL -
Mice, Knockout -
Neoplasms - enzymology
Neoplasms - genetics
Neoplasms - pathology
Phenotype -

Find related publications in this database (Keywords)
adipose triglyceride lipase
cancer metabolism
diagnostic marker
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