Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Stadlbauer, V; Leber, B; Lemesch, S; Trajanoski, S; Bashir, M; Horvath, A; Tawdrous, M; Stojakovic, T; Fauler, G; Fickert, P; Högenauer, C; Klymiuk, I; Stiegler, P; Lamprecht, M; Pieber, TR; Tripolt, NJ; Sourij, H.
Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study.
PLoS One. 2015; 10(10):e0141399-e0141399
Doi: 10.1371/journal.pone.0141399
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- Leading authors Med Uni Graz
- Leber Bettina
- Stadlbauer-Köllner Vanessa
- Trajanoski Slave
- Co-authors Med Uni Graz
- Bashir Mina
- Fauler Günter
- Fickert Peter
- Hoegenauer Christoph
- Horvath Angela
- Klymiuk Ingeborg
- Lemesch Sandra
- Pieber Thomas
- Sourij Harald
- Stiegler Philipp
- Stojakovic Tatjana
- Tawdrous Monika
- Tripolt Norbert
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- Abstract:
- Metabolic syndrome is associated with disturbances in gut microbiota composition. We aimed to investigate the effect of Lactobacillus casei Shirota (LcS) on gut microbiota composition, gut barrier integrity, intestinal inflammation and serum bile acid profile in metabolic syndrome. In a single-centre, prospective, randomised controlled pilot study, 28 subjects with metabolic syndrome received either LcS for 12 weeks (n = 13) or no LcS (n = 15). Data were compared to healthy controls (n = 16). Gut microbiota composition was characterised from stool using 454 pyrosequencing of 16S rRNA genes. Serum bile acids were quantified by tandem mass spectrometry. Zonulin and calprotectin were measured in serum and stool by ELISA. Bacteroidetes/Firmicutes ratio was significantly higher in healthy controls compared to metabolic syndrome but was not influenced by LcS. LcS supplementation led to enrichment of Parabacteroides. Zonulin and calprotectin were increased in metabolic syndrome stool samples but not influenced by LcS supplementation. Serum bile acids were similar to controls and not influenced by LcS supplementation. Metabolic syndrome is associated with a higher Bacteroidetes/Firmicutes ratio and gut barrier dysfunction but LcS was not able to change this. LcS administration was associated with subtle microbiota changes at genus level. ClinicalTrials.gov NCT01182844.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Bile Acids and Salts - metabolism
- Biodiversity -
- Biomarkers -
- Case-Control Studies -
- Female -
- Gastrointestinal Microbiome -
- Humans -
- Intestinal Mucosa - metabolism
- Intestinal Mucosa - microbiology
- Lactobacillus casei -
- Male -
- Metabolic Syndrome X - metabolism
- Metabolic Syndrome X - microbiology
- Middle Aged -
- Pilot Projects -
- Probiotics - administration & dosage