Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Trummer, O; Langsenlehner, U; Krenn-Pilko, S; Pieber, TR; Obermayer-Pietsch, B; Gerger, A; Renner, W; Langsenlehner, T.
Vitamin D and prostate cancer prognosis: a Mendelian randomization study.
World J Urol. 2016; 34(4):607-611
Doi: 10.1007/s00345-015-1646-9
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- Leading authors Med Uni Graz
- Renner Wilfried
- Trummer Olivia
- Co-authors Med Uni Graz
- Gerger Armin
- Krenn-Pilko Sabine
- Langsenlehner Tanja
- Langsenlehner Uwe
- Obermayer-Pietsch Barbara
- Pieber Thomas
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- Abstract:
- Decreased vitamin D levels have been associated with prostate cancer, but it is unclear whether this association is causal. A functional single-nucleotide polymorphism (SNP) in the group-specific component (GC) gene (T > G, rs2282679) has been associated with 25-hydroxy (25-OH) vitamin D and 1.25 dihydroxy (1.25-OH2) vitamin D levels. To examine the hypothesized inverse relationship between vitamin D status and prostate cancer, we studied the association between this SNP and prostate cancer outcome in the prospective PROCAGENE study comprising 702 prostate cancer patients with a median follow-up of 82 months. GC rs2282679 genotypes were not associated with biochemical recurrence [hazard ratios (HR) 0.91, 95 % confidence interval (CI) 0.73-1.12; p = 0.36], development of metastases (HR 1.20, 95 % CI 0.88-1.63; p = 0.25) or overall survival (HR 1.10; 95 % CI 0.84-1.43; p = 0.50). A causal role of vitamin D status, as reflected by GC rs2282679 genotype, in disease progression and mortality in prostate cancer patients is unlikely.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Austria - epidemiology
- Biomarkers, Tumor - blood
- Biomarkers, Tumor - genetics
- DNA, Neoplasm - genetics
- Disease Progression -
- Genotype -
- Humans -
- Male -
- Mendelian Randomization Analysis - methods
- Polymorphism, Single Nucleotide -
- Prognosis -
- Prospective Studies -
- Prostatic Neoplasms - blood
- Prostatic Neoplasms - genetics
- Prostatic Neoplasms - mortality
- Risk Factors -
- Survival Rate - trends
- Vitamin D-Binding Protein - blood
- Vitamin D-Binding Protein - genetics
- Find related publications in this database (Keywords)
- Vitamin D
- Prostate cancer
- Genetics