Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kraus, T; Moszner, F; Fischerauer, S; Fiedler, M; Martinelli, E; Eichler, J; Witte, F; Willbold, E; Schinhammer, M; Meischel, M; Uggowitzer, PJ; Löffler, JF; Weinberg, A.
Biodegradable Fe-based alloys for use in osteosynthesis: outcome of an in vivo study after 52 weeks.
Acta Biomater. 2014; 10(7):3346-3353
Doi: 10.1016/j.actbio.2014.04.007
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Kraus Tanja
- Weinberg Annelie-Martina
- Co-authors Med Uni Graz
- Eichler Johannes
- Fischerauer Stefan Franz
- Martinelli Elisabeth
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- Abstract:
- This study investigates the degradation performance of three Fe-based materials in a growing rat skeleton over a period of 1 year. Pins of pure Fe and two Fe-based alloys (Fe-10 Mn-1Pd and Fe-21 Mn-0.7C-1Pd, in wt.%) were implanted transcortically into the femur of 38 Sprague-Dawley rats and inspected after 4, 12, 24 and 52 weeks. The assessment was performed by ex vivo microfocus computed tomography, weight-loss determination, surface analysis of the explanted pins and histological examination. The materials investigated showed signs of degradation; however, the degradation proceeded rather slowly and no significant differences between the materials were detected. We discuss these unexpected findings on the basis of fundamental considerations regarding iron corrosion. Dense layers of degradation products were formed on the implants' surfaces, and act as barriers against oxygen transport. For the degradation of iron, however, the presence of oxygen is an indispensable prerequisite. Its availability is generally a critical factor in bony tissue and rather limited there, i.e. in the vicinity of our implants. Because of the relatively slow degradation of both pure Fe and the Fe-based alloys, their suitability for bulk temporary implants such as those in osteosynthesis applications appears questionable. Copyright © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Alloys -
- Animals -
- Biocompatible Materials -
- Iron - chemistry
- Male -
- Microscopy, Electron, Scanning -
- Osteogenesis -
- Rats -
- Rats, Sprague-Dawley -
- Find related publications in this database (Keywords)
- Iron
- Iron alloys
- Biodegradation
- Fracture fixation
- mu CT