Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Aigelsreiter, AM; Aigelsreiter, A; Wehrschuetz, M; Ress, AL; Koller, K; Salzwimmer, M; Gerger, A; Schauer, S; Bauernhofer, T; Pichler, M.
Loss of the putative tumor suppressor protein spinophilin is associated with poor prognosis in head and neck cancer.
Hum Pathol. 2014; 45(4):683-690
Doi: 10.1016/j.humpath.2013.11.014
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Aigelsreiter Alena Maria
- Aigelsreiter Ariane
- Co-authors Med Uni Graz
- Bauernhofer Thomas
- Friedrich Michaela
- Gerger Armin
- Koller Karin
- Lembeck Anna Lena
- Pichler Martin
- Schauer Silvia
- Wehrschütz Martin
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- Abstract:
- The putative tumor suppressor protein spinophilin has been recently involved in the pathogenesis of lung, liver, and other types of cancer. Previous studies also indicate that a loss of spinophilin in combination with functional impairment of p53 drives tumor progression. To date, no data exist about the role of spinophilin in head and neck squamous cell carcinoma (HNSCC). In the present study, we evaluated spinophilin and p53 expression by immunohistochemistry in 85 patients with nonmetastatic HNSCC. Kaplan-Meier curves and multivariate Cox proportional models were used to define the prognostic relevance of spinophilin for patients with HNSCC. Overall, immunoreactivity for spinophilin was reduced in 40 tumors (47%). Nine cases (10.5%) showed complete loss of spinophilin. Kaplan-Meier curve analysis demonstrated that reduced spinophilin expression is associated with poor overall survival (P = .022). Concomitant analysis of spinophilin and p53 further showed that patients with reduced spinophilin expression and nuclear p53 staining have a significantly decreased overall survival (hazard ratio, 1.96; 95% confidence interval, 1.06-3.61; P = .030). In conclusion, the combination of reduced spinophilin expression and nuclear p53 staining indicates a poor prognosis in HNSCC patients. Based on our results, spinophilin might play a previously unrecognized role in the pathogenesis of HNSCC. © 2014.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers, Tumor - analysis
- Carcinoma, Squamous Cell - metabolism
- Carcinoma, Squamous Cell - mortality
- Carcinoma, Squamous Cell - pathology
- Female -
- Head and Neck Neoplasms - metabolism
- Head and Neck Neoplasms - mortality
- Head and Neck Neoplasms - pathology
- Humans -
- Immunohistochemistry -
- Kaplan-Meier Estimate -
- Male -
- Microfilament Proteins - analysis
- Microfilament Proteins - biosynthesis
- Middle Aged -
- Nerve Tissue Proteins - analysis
- Nerve Tissue Proteins - biosynthesis
- Prognosis -
- Proportional Hazards Models -
- Squamous Cell Carcinoma of Head and Neck -
- Tumor Suppressor Protein p53 - analysis
- Tumor Suppressor Protein p53 - biosynthesis
- Find related publications in this database (Keywords)
- Head and neck cancer
- Prognosis
- Novel tumor suppressor protein