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SHR Neuro Cancer Cardio Lipid Metab Microb

Langsenlehner, T; Döller, C; Winkler, P; Gallé, G; Kapp, KS.
Impact of inter- and intrafraction deviations and residual set-up errors on PTV margins. Different alignment techniques in 3D conformal prostate cancer radiotherapy.
Strahlenther Onkol. 2013; 189(4):321-328 Doi: 10.1007/s00066-012-0303-0
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Leading authors Med Uni Graz
Langsenlehner Tanja
Co-authors Med Uni Graz
Döller Carmen
Kapp Karin S.
Winkler Peter

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The aim of this work was to analyze interfraction and intrafraction deviations and residual set-up errors (RSE) after online repositioning to determine PTV margins for 3 different alignment techniques in prostate cancer radiotherapy. The present prospective study included 44 prostate cancer patients with implanted fiducials treated with three-dimensional (3D) conformal radiotherapy. Daily localization was based on skin marks followed by marker detection using kilovoltage (kV) imaging and subsequent patient repositioning. Additionally, in-treatment megavoltage (MV) images were obtained for each treatment field. In an off-line analysis of 7,273 images, interfraction prostate motion, RSE after marker-based prostate localization, prostate position during each treatment session, and the effect of treatment time on intrafraction deviations were analyzed to evaluate PTV margins. Margins accounting for interfraction deviation, RSE and intrafraction motion were 14.1, 12.9, and 15.1 mm in anterior-posterior (AP), superior-inferior (SI), and left-right (LR) direction for skin mark alignment and 9.6, 8.7, and 2.6 mm for bony structure alignment, respectively. Alignment to implanted markers required margins of 4.6, 2.8, and 2.5 mm. As margins to account for intrafraction motion increased with treatment prolongation PTV margins could be reduced to 3.9, 2.6, and 2.4 mm if treatment time was ≤ 4 min. With daily online correction and repositioning based on implanted fiducials, a significant reduction of PTV margins can be achieved. The use of an optimized workflow with faster treatment techniques such as volumetric modulated arc techniques (VMAT) could allow for a further decrease.
Find related publications in this database (using NLM MeSH Indexing)
Adenocarcinoma - pathology
Adenocarcinoma - radiotherapy
Dose Fractionation, Radiation -
Fiducial Markers -
Humans -
Male -
Patient Positioning - methods
Prostatic Neoplasms - pathology
Prostatic Neoplasms - radiotherapy
Radiation Injuries - prevention & control
Radiotherapy Dosage -
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Conformal - methods
Radiotherapy, High-Energy - methods
Rectum - radiation effects
Tomography, X-Ray Computed - methods
Urinary Bladder - radiation effects

Find related publications in this database (Keywords)
Prostate neoplasms
Image-guided radiotherapy
Planning target volume margins
Radiotherapy setup errors
Fiducial markers
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