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SHR Neuro Cancer Cardio Lipid Metab Microb

Wagner, D; Amrein, K; Dimai, HP; Kniepeiss, D; Tscheliessnigg, KH; Kornprat, P; Dobnig, H; Pieber, T; Fahrleitner-Pammer, A.
Ibandronate and calcitriol reduces fracture risk, reverses bone loss, and normalizes bone turnover after LTX.
Transplantation. 2012; 93(3):331-336 Doi: 10.1097/TP.0b013e31823f7f68 [OPEN ACCESS]
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Leading authors Med Uni Graz
Wagner Doris
Co-authors Med Uni Graz
Amrein Karin
Dimai Hans Peter
Dobnig Harald
Fahrleitner-Pammer Astrid
Kniepeiss Daniela
Kornprat Peter
Pieber Thomas
Tscheliessnigg Karlheinz

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Osteoporosis is a common complication in long-term survivors after liver transplantation (LTX). This study investigates the influence of a combination therapy of low dose parenteral ibandronate (IBN) and calcitriol on top of calcium and vitamin D supplementation in such patients. For 3 years, 30 osteoporotic patients after LTX (28±6 months) were treated with quarterly 2 mg IBN intravenously and daily calcitriol (0.25-1.0 μg) on top of 1000 mg calcium and 800 IU vitamin D. Recipients with normal bone density (n=24) were enrolled as controls. Laboratory analysis and dual energy X-ray absorptiometry were performed at baseline and every 12 months. Primary endpoints were changes in bone mineral density and fracture incidence. IBN patients showed a significant increase of bone mineral density at the femoral neck and the trochanteric region (13% and 15%, respectively, both P=0.001) as compared with baseline whereas the control group revealed a small but significant loss of -5.0% in the trochanteric and -4.9% in the neck region (P<0.05) over the same time period. Fracture incidence was low among IBN patients (7%); however, 23% of the control patients sustained at least one vertebral fracture. The relative fracture risk was 3.21 for IBN patients (95% confidence interval, 0.6-20.9, P=0.03) resulting in an absolute risk reduction for a new vertebral fracture of 14%. In LTX recipients with osteoporosis combination therapy with low dose IBN and calcitriol on top of calcium and vitamin D supplementation is an effective treatment option.
Find related publications in this database (using NLM MeSH Indexing)
Alkaline Phosphatase - blood
Bone Density -
Bone Density Conservation Agents - administration & dosage
Bone Remodeling - drug effects
Calcitriol - administration & dosage
Diphosphonates - administration & dosage
Drug Therapy, Combination -
Female -
Fractures, Bone - prevention & control
Humans -
Liver Transplantation - adverse effects
Male -
Middle Aged -
Osteoporosis - drug therapy
Parathyroid Hormone - blood
Risk -

Find related publications in this database (Keywords)
Liver transplantation
Secondary hyperparathyroidism
Renal insufficiency
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