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SHR Neuro Cancer Cardio Lipid

Brcic, L; Kern, I.
Clinical significance of histologic subtyping of malignant pleural mesothelioma.
Transl Lung Cancer Res. 2020; 9(3): 924-933. [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

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Brcic Luka
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Abstract:
Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite multimodality treatments 5-year survival is only 5% after the diagnosis. Histology and TNM staging system are still the best prognostic factors. Furthermore, histologic subtype of MM determines the clinical management of the patients. According to the 2015 WHO classification, MM is divided into diffuse, localized and well differentiated papillary mesothelioma. Major histologic subtypes of diffuse MM, namely epithelioid, biphasic and sarcomatoid, have different prognosis. However, in the last decade it has become evident that more detailed subclassification and histologic/cytological characterization of MM have prognostic and perhaps predictive implications. In this review, major histologic subtypes and cytological features of MM are presented and their relation with prognosis and predictive biomarkers is discussed. 2020 Translational Lung Cancer Research. All rights reserved.

Find related publications in this database (Keywords)
Malignant mesothelioma (MM)
epithelioid malignant mesothelioma
biphasic malignant mesothelioma
sarcomatoid malignant mesothelioma (SMM)
histology
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