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SHR Neuro Cancer Cardio Lipid

Smolle, MA; Schaffler, A; Leithner, A; Van Praag, VM; Bergovec, M; Szkandera, J; Liegl-Atzwanger, B; Niethard, M; Tunn, PU; Van De Sande, M; Andreou, D.
Incidence, treatment and outcome of abdominal metastases in extremity soft tissue sarcoma: Results from a multi-centre study.
J Surg Oncol. 2020; [OPEN ACCESS]
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Authors Med Uni Graz:
Bergovec Marko
Leithner Andreas
Liegl-Atzwanger Bernadette
Smolle Maria
Szkandera Joanna
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Abstract:
Abdominal metastases (AM) from soft tissue sarcoma (STS) are rare and prognosis is poor. The aims of the study were to (a) identify risk factors for the development of AM and to (b) investigate the outcome of AM-patients. Seven-hundred-sixty-nine STS-patients with localised disease at diagnosis treated at three tumour centres (2000-2016) were retrospectively included (409 males; mean age, 55.6 years [range, 8-96 years]; median follow-up, 4.1 years [interquartile-range, 2.5-6.6 years]). Two-hundred-two patients (26.3%) developed secondary metastases, and 24 of them AM (3.1%). Ten patients developed first AM (FAM) after a mean of 2.4 years and 14 patients late AM (LAM, after being diagnosed with metastases to other sites) after a mean of 2.0 years. Patients with liposarcoma had a significantly higher risk of developing AM (P = .007), irrespective of grading. There was no difference in post-metastasis-survival (PMS) between patients with AM at any time point and those with metastases to other sites (P = .585). Patients with LAM or FAM showed no difference in post-abdominal-metastasis-survival (P = .884). Survival in patients with AM is poor, irrespective of whether they develop secondarily to other metastases or not. Patients at high-risk of AM (ie, liposarcoma) may be followed-up regularly by abdominal-ultrasound/CT. © 2020 The Authors. Journal of Surgical Oncology published by Wiley Periodicals, Inc.

Find related publications in this database (Keywords)
abdominal metastasis
soft tissue sarcoma
survival
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