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Beer, M; Winkelmann, V; Becker, JC; Terheyden, P; Stenzel, M; Brocker, EB; Hahn, D; Kostler, H.
Spectroscopic imaging of the human liver using 3D CSI: optimization and application in patients with metastatic uvea melanoma
Rofo. 2009; 181(1):60-66 [OPEN ACCESS]
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Autor/innen der Med Uni Graz:
Becker Jürgen Christian
Beer Meinrad

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PURPOSE: (31)P MR spectroscopy (MRS) allows the noninvasive assessment of metabolic alterations in tumors. Due to physical as well as technical limitations, mostly large and single voxels are used. We used a spatially resolved (31)P MRS technique to characterize metabolic abnormalities inside and adjacent to liver metastases of patients with uvea melanoma. MATERIALS AND METHODS: Optimization of 3D chemical shift imaging (3D CSI) was performed in healthy volunteers (n = 19; voxel size 25 ml). Patients (n = 8) with liver metastases were then examined. Cross sectional imaging was available for all patients. RESULTS: Compared to healthy volunteers, the PME/PDE ratios of patients with liver metastasis were significantly higher (0.56 +/- 0.30 vs. 0.39 +/- 0.21; p < 0.05). A trend towards increased PME/beta ATP ratios (2.07 +/- 1.83 vs. 1.02 +/- 0.45; p = 0.12) and decreased Pi/PME ratios (0.57 +/- 0.29 vs. 1.06 +/- 0.58; p = 0.06) was also observed. Patients with metastases > or = 5 cm showed significantly higher PME/PDE ratios (0.68 +/- 0.17 vs. 0.45 +/- 0.03; p < 0.05). Liver parenchyma adjacent to metastases did not show any significant changes compared to non-diseased tissue. CONCLUSION: 3D CSI allows the simultaneous analysis of metabolic alterations in diseased as well as in healthy human liver. Metastases show significant metabolic alterations. Thus, (31)P MRS opens new possibilities for therapeutic monitoring.
Find related publications in this database (using NLM MeSH Indexing)
Adenosine Triphosphate - metabolism
Adult -
Aged -
Choroid Neoplasms - diagnosis Choroid Neoplasms - physiopathology
Energy Metabolism - physiology
Female -
Humans -
Image Processing, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Liver - physiopathology
Liver Neoplasms - diagnosis Liver Neoplasms - physiopathology Liver Neoplasms - secondary
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Male -
Melanoma - diagnosis Melanoma - physiopathology Melanoma - secondary
Middle Aged -
Observer Variation -
Phosphocreatine - metabolism
Phospholipids - metabolism
Reference Values -
Sensitivity and Specificity -
Young Adult -

Find related publications in this database (Keywords)
molecular analysis
tissue characterization
treatment planning
MR spectroscopy
liver metastasis
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