Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Leukauf, C; Szeles, C; Salaymeh, L; Grimm, M; Grabenwöger, M; Losert, U; Moritz, A; Wolner, E.
In vitro and in vivo endothelialization of glutaraldehyde treated bovine pericardium.
J Heart Valve Dis. 1993; 2(2): 230-235.


Autor/innen der Med Uni Graz:
Salaymeh Luay

Dimensions Citations:

Plum Analytics:
In an experimental study, endothelial cell seeding on glutaraldehyde-fixed and detoxified bioprosthetic tissue, suitable for valve fabrication, was investigated in vitro. These findings were compared to spontaneous endothelial cell ingrowth on vascular grafts fabricated from the same materials. Special consideration was given to the quality of cell attachment with regards to improved shear stress resistance in the endothelial layer covering the bioprosthetic surface. On glutaraldehyde detoxified bovine pericardium, in vitro endothelial cell seeding resulted in uninhibited cell proliferation, but the cells were loosely bound to the underlying tissue. In vivo, endothelial cells grew spontaneously over the surface of vascular implants in direct contact with the bioprosthetic material. In contrast to standard fixed bovine pericardium, a significant decrease in thrombotic appositions could be observed. Cells exhibited intensive production of extracellular matrix, which renders the method of spontaneous in vivo cell ingrowth as the most promising approach for further research.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Aorta - surgery
Basement Membrane - ultrastructure
Bioprosthesis -
Cattle -
Cell Adhesion -
Cell Death -
Collagen -
Elastin -
Endothelium, Vascular - cytology Endothelium, Vascular - physiology
Extracellular Matrix - ultrastructure
Glutamates - chemistry
Glutamic Acid -
Glutaral - chemistry
Microscopy, Electron -
Microscopy, Electron, Scanning -
Pericardium -
Sheep -
Surface Properties -
Thrombosis - pathology
Tissue Fixation -
Tissue Preservation -

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