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Halwachs-Baumann, G.
Recent developments in human cytomegalovirus diagnosis.
Expert Rev Anti Infect Ther. 2007; 5(3): 427-439. Doi: 10.1586/14787210.5.3.427
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Führende Autor*innen der Med Uni Graz
Baumann Gabriele

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Since the early 1990s, great efforts have been made in the field of human cytomegalovirus (HCMV) diagnosis. Besides HCMV diagnosis in immunosuppressed patients (solid organ transplant recipients, hematopoietic stem cell transplant patients and AIDS patients), diagnosis in connection with congenital HCMV infection is of great interest. This review focuses on the development and clinical utility of serological assays, as well as on virological tests (molecular and nonmolecular assays). Interpretation of these tests is strongly dependent on the patient group (solid organ transplant recipients and hematopoietic stem cell transplant patients) and whether the tests are used for screening, risk stratification or diagnosis. Furthermore, a better understanding of HCMV infection has led to new approaches in HCMV diagnosis and monitoring. Thus, assays for viral resistance testing and assays for monitoring the HCMV-specific cellular immune response are increasingly important for the guidance of antiviral therapy.
Find related publications in this database (using NLM MeSH Indexing)
Bodily Secretions - virology
Body Fluids - virology
Cytomegalovirus - genetics Cytomegalovirus - isolation and purification Cytomegalovirus - pathogenicity
Cytomegalovirus Infections - complications Cytomegalovirus Infections - congenital Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - immunology
DNA, Viral - analysis DNA, Viral - blood
HIV Infections - complications
Humans -
Microbial Sensitivity Tests -
Polymerase Chain Reaction -
RNA, Viral - analysis RNA, Viral - blood
Serologic Tests -
Transplantation - adverse effects

Find related publications in this database (Keywords)
congenital HCMV
HCMV diagnosis
immunological monitoring
molecular-based assays
resistance testing
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