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SHR Neuro Krebs Kardio Lipid

Wolf, P; Byrne, SN; Gruber-Wackernagel, A.
New insights into the mechanisms of polymorphic light eruption: resistance to ultraviolet radiation-induced immune suppression as an aetiological factor.
EXP DERMATOL. 2009; 18(4): 350-356. [OPEN ACCESS]
Web of Science PubMed

 

Autor/innen der Med Uni Graz:
Gruber-Wackernagel Alexandra
Wolf Peter
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Abstract:
An abnormal immune response has long been thought responsible for the patho-aetiology of polymorphic light eruption, the most common photodermatosis. Recent evidence indicates that polymorphic light eruption patients are resistant to the immune suppressive effects of sunlight, a phenomenon that leads to the formation of skin lesions upon seasonal sun exposure. This immunological abnormality in polymorphic light eruption supports the concept of the biological significance and evolutionary logic of sunlight-induced immune suppression, i.e. the prevention of immune responses to photo-induced neo-antigens in the skin, thereby preventing autoimmunity and skin rashes. This article focuses on the immunological alterations in polymorphic light eruption and the pathogenic significance to the disease state and skin carcinogenesis.
Find related publications in this database (using NLM MeSH Indexing)
Autoimmunity -
Humans -
Immune System - immunology
Immunosuppression -
Neoplasms, Radiation-Induced - epidemiology
Photosensitivity Disorders - etiology
Risk Factors -
Skin Neoplasms - epidemiology
Ultraviolet Rays - adverse effects

Find related publications in this database (Keywords)
immune suppression
polymorphic light eruption
T regulatory cells
UV radiation
UV resistance
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