Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Smolle, J; Kaudewitz, P; Aberer, E; Torne, R; Burg, G; Kerl, H.
Immunohistochemical classification of cutaneous lymphomas and pseudolymphomas
HAUTARZT. 1987; 38(8): 461-466.
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Autor/innen der Med Uni Graz:
Aberer Elisabeth
Kerl Helmut
Smolle Josef

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We investigated 46 cases of cutaneous lymphoma and pseudolymphoma by immunohistochemical methods using a panel of monoclonal antibodies. Of the cutaneous T cell lymphomas, 2 did not show the classic helper phenotype but revealed a predominance of suppressor cells in one case and of immature thymocytes in the other. Cutaneous B cell lymphomas of low-grade malignancy were characterized by the presence of completely developed T zones between the B cell areas. B cell lymphomas of high-grade malignancy revealed an immunohistologically homogeneous infiltrate. Cutaneous pseudolymphomas can be classified in T cell pseudolymphomas (lymphocytic infiltration, lymphomatoid papulosis) and B cell pseudolymphomas. Lymphadenosis cutis benigna with germinal center cell differentiation was clearly distinguishable from other B cell pseudolymphomas, which are considered to comprise mainly peripheral B lymphocytes. Immunohistological methods are obviously useful in the classification of lymphoproliferative diseases of the skin and can make a contribution to increasing our understanding of them.
Find related publications in this database (using NLM MeSH Indexing)
Antibodies, Monoclonal - diagnostic use
Antigens, Neoplasm - immunology
Antigens, Surface - immunology
B-Lymphocytes - pathology
Biopsy - pathology
Humans - pathology
Immunoenzyme Techniques - pathology
Lymphoma - classification
Skin Neoplasms - classification
T-Lymphocytes - pathology

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