Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fröhlich, E; Brossart, P; Wahl, R.
Induction of iodide uptake in transformed thyrocytes: a compound screening in cell lines.
Eur J Nucl Med Mol Imaging. 2009; 36(5):780-790
Doi: 10.1007/s00259-008-1024-6
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Fröhlich Eleonore
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- Abstract:
- Retinoic acid presently is the most advanced agent able to improve the efficacy of radioiodine therapy in differentiated thyroid carcinoma. In order to identify compounds with higher efficacy a panel of pharmacologically well-characterized compounds with antitumour action in solid cancer cell lines was screened. The effects of the compounds on iodide uptake, cell number, proliferation and apoptosis were evaluated. In general, compounds were more effective in cell lines derived from more aggressive tumours. The effectiveness in terms of number of responsive cell lines and maximal increase in iodide uptake achieved decreased in the order: APHA > valproic acid a parts per thousand sirolimus a parts per thousand arsenic trioxide > retinoic acid a parts per thousand lovastatin > apicidine a parts per thousand azacytidine a parts per thousand retinol a parts per thousand rosiglitazone a parts per thousand bortezomib. We hypothesize that testing of cells from primary tumours or metastases in patients may be a way to identify compounds with optimum therapeutic efficacy for individualized treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - pharmacology
- Apoptosis -
- Arsenicals - pharmacology
- Boronic Acids - pharmacology
- Carcinoma - metabolism
- Cell Differentiation -
- Cell Line, Tumor -
- Cell Proliferation -
- Drug Screening Assays, Antitumor -
- Humans -
- Iodides - metabolism
- Lovastatin - pharmacology
- Neoplasm Metastasis -
- Oxides - pharmacology
- Pyrazines - pharmacology
- Sirolimus - pharmacology
- Thymus Gland - cytology
- Thyroid Neoplasms - metabolism
- Tretinoin - metabolism
- Find related publications in this database (Keywords)
- Thyroid carcinoma
- Differentiation therapy
- HDAC inhibitors
- Retinoids
- Glitazones
- Mevinolin
- Bortezomib
- Sirolimus
- Arsenic trioxide