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Fröhlich, E; Brossart, P; Wahl, R.
Induction of iodide uptake in transformed thyrocytes: a compound screening in cell lines.
Eur J Nucl Med Mol Imaging. 2009; 36(5):780-790 Doi: 10.1007/s00259-008-1024-6
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Fröhlich Eleonore

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Retinoic acid presently is the most advanced agent able to improve the efficacy of radioiodine therapy in differentiated thyroid carcinoma. In order to identify compounds with higher efficacy a panel of pharmacologically well-characterized compounds with antitumour action in solid cancer cell lines was screened. The effects of the compounds on iodide uptake, cell number, proliferation and apoptosis were evaluated. In general, compounds were more effective in cell lines derived from more aggressive tumours. The effectiveness in terms of number of responsive cell lines and maximal increase in iodide uptake achieved decreased in the order: APHA > valproic acid a parts per thousand sirolimus a parts per thousand arsenic trioxide > retinoic acid a parts per thousand lovastatin > apicidine a parts per thousand azacytidine a parts per thousand retinol a parts per thousand rosiglitazone a parts per thousand bortezomib. We hypothesize that testing of cells from primary tumours or metastases in patients may be a way to identify compounds with optimum therapeutic efficacy for individualized treatment.
Find related publications in this database (using NLM MeSH Indexing)
Antineoplastic Agents - pharmacology
Apoptosis -
Arsenicals - pharmacology
Boronic Acids - pharmacology
Carcinoma - metabolism
Cell Differentiation -
Cell Line, Tumor -
Cell Proliferation -
Drug Screening Assays, Antitumor -
Humans -
Iodides - metabolism
Lovastatin - pharmacology
Neoplasm Metastasis -
Oxides - pharmacology
Pyrazines - pharmacology
Sirolimus - pharmacology
Thymus Gland - cytology
Thyroid Neoplasms - metabolism
Tretinoin - metabolism

Find related publications in this database (Keywords)
Thyroid carcinoma
Differentiation therapy
HDAC inhibitors
Arsenic trioxide
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