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SHR Neuro Krebs Kardio Lipid

Fuchs, R; Stelzer, I; Haas, HS; Leitinger, G; Schauenstein, K; Sadjak, A.
The alpha1-adrenergic receptor antagonists, benoxathian and prazosin, induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells.
Ann Hematol. 2009; 88(10): 989-997.
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Autor/innen der Med Uni Graz:
Fuchs Robert
Haas Helga Susanne
Leitinger Gerd
Sadjak Anton
Stelzer Ingeborg
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Abstract:
The erythroleukemia cell lines K562 and human erythroleukemia (HEL) are established models to study erythroid and megakaryocytic differentiation in vitro. In this study, we show that the alpha1-adrenergic antagonists, benoxathian and prazosin, inhibit the proliferation and induce apoptosis in K562 and HEL cells. Furthermore, both tested substances induced the expression of the megakaryocytic marker CD41a, whereas the expression of the erythroid marker glycophorin-a was decreased or unchanged. Even though the expression of differentiation markers was similar after benoxathian and prazosin treatment in both cell lines, endomitosis of erythroleukemia cells was observed only after prazosin treatment. So far, benoxathian and prazosin are the first described extracellular ligands, which cause megakaryocytic differentiation in K562 and HEL cells. In summary, these results indicate a possible role of alpha1-adrenergic receptor signaling in the regulation of erythroid and megakaryocytic differentiation, even though the receptor dependence of the observed effects needs further investigation.
Find related publications in this database (using NLM MeSH Indexing)
Adrenergic alpha-Antagonists - pharmacology
Apoptosis - drug effects
Cell Differentiation - drug effects
Cell Line, Tumor -
Erythroid Cells -
Humans -
K562 Cells -
Leukemia, Erythroblastic, Acute - drug therapy
Megakaryocytes - cytology
Oxathiins - pharmacology
Prazosin - pharmacology
Receptors, Adrenergic, alpha-1 - metabolism

Find related publications in this database (Keywords)
Erythroleukemia cells
alpha 1-adrenergic antagonists
Apoptosis
Erythroid differentiation
Megakaryocytic differentiation
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