Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Smolle, J; Soyer, HP; Ehall, R; Stettner, H; Kerl, H.
NK cell density in malignant skin tumours--a stereological study.
BRIT J DERMATOL 1987 116: 823-829.
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Autor/innen der Med Uni Graz:
Kerl Helmut
Smolle Josef
Soyer Hans Peter
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Abstract:
We determined the density of natural killer (NK) cells in frozen sections of malignant melanoma (nine cases), squamous cell carcinoma (six cases) and non-neoplastic tonsil (five cases) by immunohistological and stereological methods. The mean density of NK cells in malignant melanoma (5.0 +/- 1.5 X 10(3)/mm3) and in squamous cell carcinoma (5.1 +/- 2.7 X 10(3)/mm3) was significantly lower than in germinal centres of normal human tonsils (5.0 +/- 0.8 X 10(4)/mm3). The NK cell/tumour cell ratio (0.03 +/- 0.015 in malignant melanoma and 0.02 +/- 0.015 in squamous cell carcinoma) is 10(2)-10(4) times lower than that commonly used for in vitro assays. The possible role of NK cells in malignant skin tumours should be viewed with caution.
Find related publications in this database (using NLM MeSH Indexing)
Biopsy -
Carcinoma, Squamous Cell - immunology
Cell Count - immunology
Humans - immunology
Killer Cells, Natural - immunology
Melanoma - immunology
Research Support, Non-U.S. Gov't - immunology
Skin - pathology
Skin Neoplasms - immunology
Tonsil - pathology

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