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Slater, TF; Bajardi, F; Benedetto, C; Bussolati, G; Cianfano, S; Dianzani, MU; Ghiringhello, B; Nöhammer, G; Rojanapo, W; Schauenstein, E.
Protein thiols in normal and neoplastic human uterine cervix.
FEBS Lett. 1985; 187(2):267-271
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Protein-thiol groups that react with dihydroxydinaphthyl disulphide during a 7 h incubation (so-called reactive protein thiols, PSHr) have been quantitatively measured on sections of human uterine cervix by microcytospectrophotometry. Measurements were made on areas (1 micron 2) of epithelium and adjoining stroma in samples of normal cervix, and in samples obtained from patients with dysplasia, carcinoma-in-situ and invasive cancer. The ratio of PSHr in epithelium to stroma is substantially reduced in the pathological conditions compared with normal and in apparently normal adjacent areas. Such changes in PSHr are discussed in relation to the redox balance of the tissue, and free radical disturbances previously described.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Carcinoma in Situ - metabolism
Cervix Uteri - metabolism
Epithelium - metabolism
Female - metabolism
Free Radicals - metabolism
Humans - metabolism
Middle Aged - metabolism
Oxidation-Reduction - metabolism
Proteins - metabolism
Sulfhydryl Compounds - metabolism
Uterine Cervical Dysplasia - metabolism
Uterine Cervical Neoplasms - metabolism

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