Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Smolle, J.
HLA-DR-antigen bearing keratinocytes in various dermatologic disorders.
Acta Derm Venereol. 1985; 65(1):9-13
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Autor/innen der Med Uni Graz:
Smolle Josef
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Abstract:
In normal human epidermis HLA-DR-antigen is only present on Langerhans' cells and the acrosyringeal epithelium. We investigated the distribution of HLA-DR-antigen in 78 specimens of various skin diseases by an immunoperoxidase method using a monoclonal anti-HLA-DR antibody. HLA-DR-antigen bearing keratinocytes were not only found in lichen planus and mycosis fungoides, as it has been referred previously, but were also observed in some cases of cutaneous B-cell lymphoma, pseudolymphoma, lupus erythematosus, parapsoriasis en plaque, bullous pemphigoid, drug reaction, contact dermatitis, actinic keratosis and verrucous carcinoma. Direct contact of lymphoid cells with keratinocytes was not necessary for Ia-antigen expression.
Find related publications in this database (using NLM MeSH Indexing)
Antibodies, Monoclonal - analysis
Dermatitis, Contact - genetics
Gene Expression Regulation - genetics
HLA-DR Antigens - genetics
Histocompatibility Antigens Class II - genetics
Humans - genetics
Immunoenzyme Techniques - genetics
Leukemia, Lymphocytic - genetics
Lichen Planus - genetics
Lupus Erythematosus, Systemic - genetics
Psoriasis - genetics
Skin - pathology
Skin Diseases - genetics
Skin Diseases, Vesiculobullous - genetics
Skin Neoplasms - genetics

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