Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Deutsch, AJ; Frühwirth, M; Aigelsreiter, A; Cerroni, L; Neumeister, P.
Primary cutaneous marginal zone B-cell lymphomas are targeted by aberrant somatic hypermutation.
J Invest Dermatol. 2009; 129(2): 476-479. [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Aigelsreiter Ariane
Cerroni Lorenzo
Deutsch Alexander
Frühwirth Margareta
Neumeister Peter

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

A mechanism inducing genetic instability, termed aberrant somatic hypermutation (ASHM), has been described in diffuse large B-cell lymphoma. To further investigate whether ASHM also occurs in primary cutaneous marginal zone B-cell lymphoma (PCMZL), we studied the mutational profile of PAX5, RhoH/TTF, cMYC, and PIM1 in 11 PCMZLs. A total of 17 sequence variants were found in 8 of 11 lymphomas cases (72.7%), and they displayed the molecular features typical for the ASHM. Further, two mutations, one mutation in PIM1 and one in cMYC, led to amino-acid substitution with potential functional consequences. These data indicate that ASHM is associated with PCMZLs. By mutating regulatory and coding sequences of the targeted genes, ASHM may represent a major contributor to their pathogenesis.
Find related publications in this database (using NLM MeSH Indexing)
Amino Acid Substitution - genetics
B-Cell-Specific Activator Protein - genetics
DNA Mutational Analysis -
Genomic Instability -
Humans -
Lymphoma, B-Cell - genetics
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-pim-1 - genetics
Skin Neoplasms - genetics
Somatic Hypermutation, Immunoglobulin -
Transcription Factors - genetics
rho GTP-Binding Proteins - genetics

© Med Uni Graz Impressum